1 Result for "

Cardiosafety

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1 Results for "Cardiosafety" in MCE Product Catalog:

Artemisinin B
Artemisinin B
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Cat. No.: HY-125447
CAS No.: 145941-07-7
Category:  

Terpenoids Sesquiterpenes Asteraceae Plants

Target:  

Toll-like Receptor (TLR) MyD88 NF-κB RGS Protein

Artemisinin B is an orally active sesquiterpene natural product with anti-neuroinflammatory activity, which can be found in Artemisia annua Linn.. Artemisinin B suppresses the TLR4-MyD88-NF-κB signaling pathway by reducing the protein levels of TLR4 and MyD88, as well as inhibiting the mRNA expression of NF-κB p65. Artemisinin B reduces the expression of pro-inflammatory cytokines and attenuates synaptic loss, which can be used for the research of cognitive and behavioral impairments in Alzheimer's disease. Artemisinin B shows no cytotoxicity against human cardiomyocytes and exhibits very weak binding to hERG, suggesting its potential for cardioprotective property research .
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