145941-07-7
Chemical Structure
Artemisinin B
- CAS No.: 145941-07-7
- Formula:C15H22O4
- Molecular Weight:266.33
IUPAC Name: 2-((1S,4R,4aS,8R,8aR)-8,8a-dihydroxy-4,7-dimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)acrylic acid
InChIKey: PVBSTLWHHZPUSK-JDRMZHCHSA-N
SMILES: O[C@@]12[C@@H](CC[C@H]([C@]1([H])CC=C([C@H]2O)C)C)C(C(O)=O)=C
Biological Activity: Artemisinin B is an orally active sesquiterpene natural product with anti-neuroinflammatory activity, which can be found in Artemisia annua Linn.. Artemisinin B suppresses the TLR4-MyD88-NF-κB signaling pathway by reducing the protein levels of TLR4 and MyD88, as well as inhibiting the mRNA expression of NF-κB p65. Artemisinin B reduces the expression of pro-inflammatory cytokines and attenuates synaptic loss, which can be used for the research of cognitive and behavioral impairments in Alzheimer's disease. Artemisinin B shows no cytotoxicity against human cardiomyocytes and exhibits very weak binding to hERG, suggesting its potential for cardioprotective property research[1][2].
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Artemisinin B | Artemisinin B is an orally active sesquiterpene natural product with anti-neuroinflammatory activity, which can be found in Artemisia annua Linn.. Artemisinin B suppresses the TLR4-MyD88-NF-κB signaling pathway by reducing the protein levels of TLR4 and MyD88, as well as inhibiting the mRNA expression of NF-κB p65. Artemisinin B reduces the expression of pro-inflammatory cytokines and attenuates synaptic loss, which can be used for the research of cognitive and behavioral impairments in Alzheimer's disease. Artemisinin B shows no cytotoxicity against human cardiomyocytes and exhibits very weak binding to hERG, suggesting its potential for cardioprotective property research. | |||||||||||||||||||||
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References
- [1]. Qiang W, et al. Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation. Neuroscience. 2018 Dec 15;395:1-12. [Content Brief]
- [2]. Kadioglu O, et al. Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation. Arch Toxicol. 2021 Jul;95(7):2485-2495. [Content Brief]
