1 Result for "

Chalcomoracin

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Chalcomoracin" in MCE Product Catalog:

Chalcomoracin
Chalcomoracin
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Cat. No.: HY-N20674
CAS No.: 76472-89-4
Category:  

Morus alba L. Phenols Polyphenols Plants Moraceae

Target:  

ERK JNK p38 MAPK PERK mTOR Akt MDM-2/p53 PINK1/Parkin Apoptosis Reactive Oxygen Species (ROS) Paraptosis Mitophagy Autophagy Bacterial Glycosidase

Chalcomoracin is an orally active anticancer agent. Chalcomoracin exhibits anticancer, antibacterial, and α-glucosidase inhibitory activities, with an IC50 of 14.23 µM against yeast α-glucosidase and an IC50 of 5.5 μM against FabI of Staphylococcus aureus. Chalcomoracin reduces the phosphorylation levels of ERK, JNK, and P38; enhances the phosphorylation level of ERK1/2; regulates the MAPK, mTOR, AKT, and p53 signaling pathways; upregulates the expression of Chop, Bip, PINK1, GRP78, and GADD153; and downregulates the expression of Alix. Chalcomoracin induces apoptosis (apoptosis), endoplasmic reticulum stress (endoplasmic reticulum stress), paraptosis (paraptosis), ROS production, mitophagy (mitophagy), and autophagy (autophagy); it inhibits cancer cell viability, colony-forming ability, migration, invasion, proliferation, tumorigenesis, fatty acid synthesis, S. aureus growth, vitreous-stimulated retinal cell activity, and cell cycle progression at the G0/G1 phase. Chalcomoracin can be used in research related to hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, prostate cancer, proliferative vitreoretinopathy, pancreatic cancer, diabetes, and bacterial infections .
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