3 Results for "

Clostridium difficile Toxin B

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Clostridium difficile Toxin B" in MCE Product Catalog:

1
Bezlotoxumab
Bezlotoxumab
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1 Cited Publications
Cat. No.: HY-P9929
CAS No.: 1246264-45-8
Synonyms: BLA761046; MBL-CDB1; MDX-1388

Target:  

Bacterial

Research Areas:  

Infection

Bezlotoxumab (BLA761046; MBL-CDB1; MDX-1388) is a fully humanized IgG1/kappa monoclonal antibody directed against Clostridium difficile toxin B. Bezlotoxumab mediates the early reconstitution of gut microbiota to reduce the risk of recurrent Clostridium difficile infection (CDI). Bezlotoxumab can be used for the study of recurrent Clostridium difficile infection prevention .
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Methyl cholate
Methyl cholate
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Cat. No.: HY-107830
CAS No.: 1448-36-8
Purity:  99.81%
Category:  

Microorganisms Metabolic Disease Disease Research Fields Steroids

Target:  

Endogenous Metabolite Collagen

Methyl cholate is a bile acid analog and a specific inhibitor of TcdB toxin from Clostridioides difficile. Methyl cholate exerts a stronger selective inhibitory effect on TcdB than on TcdA. Methyl cholate induces conformational stabilization by binding to a unique site of TcdB, thereby blocking the binding of the toxin to host receptors and its self-processing process. Methyl cholate effectively protects human fibroblasts from TcdB-induced cytopathic effects. Methyl cholate exhibits dose-dependent anti-hepatic fibrosis activity in both cellular and zebrafish models, and significantly reduces the expression levels of α-SMA and COL-I. Methyl cholate is suitable for in-depth research in the fields of Clostridioides difficile infection and hepatic fibrosis .
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FZD7 antagonist 1
FZD7 antagonist 1
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Cat. No.: HY-P10204
CAS No.: 2416664-25-8
Target:  

Wnt

Research Areas:  

Cancer

FZD7 antagonist 1 (peptide 34) is a dFz7-21 analogue. FZD7 antagonist 1 is an FZD7 antagonist that inhibits the wnt3a with IC50 value of 9.2 nM. FZD7 antagonist 1 blocks TcdB−FZD interaction via targeting FZD receptors .
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