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Cat. No.: HY-P10204

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FZD7 antagonist 1

FZD7 antagonist 1 (peptide 34) is a dFz7-21 analogue. FZD7 antagonist 1 is an FZD7 antagonist that inhibits the wnt3a with IC₅₀ value of 9.2 nM. FZD7 antagonist 1 blocks TcdB−FZD interaction via targeting FZD receptors.

For research use only. We do not sell to patients.

CAS No.: 2416664-25-8
Formula: C₁₄₂H₂₀₂N₃₂O₄₂S₄
Molecular Weight:3157.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FZD7 antagonist 1 Chemical Structure

CAS No.: 2416664-25-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Wnt Isoforms :

Chemical Information

CAS No. 2416664-25-8
Molecular Weight 3157.57
Formula C₁₄₂H₂₀₂N₃₂O₄₂S₄
Sequence

Chain 1: Ac-Thr-Asp-Asp-Leu-Glu-Leu-Trp-Cys-His-Ile-Met-Tyr-NH2; Chain 2: Ac-Thr-Asp-Asp-Leu-Glu-Leu-Trp-Cys-His-Ile-Met-Tyr-NH2 (Disulfide bridge: Chain 1: Cys8-Chain 2: Cys8)
Sequence Shortening

Chain 1: Ac-TDDLELWCHIMY-NH2; Chain 2: Ac-TDDLELWCHIMY-NH2 (Disulfide bridge: Chain 1: Cys8-Chain 2: Cys8)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Simon Hansen, et al. Lead Optimization Yields High Affinity Frizzled 7-Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells. J Med Chem. 2019, 62, 17. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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