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Results for "

Cyr61

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) PROTACs (1) Small Interfering RNA (siRNA) (3) Survivin (1) TAM Receptor (1) YAP (13)
By Research Areas:	Cancer (13) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-158342

PROTAC TEAD degrader-1	PROTACs YAP	Cancer
PROTAC TEAD degrader-1 is a TEAD2 degrader and antiproliferative agent with selective activity toward TEAD2 relative to other TEAD family members. PROTAC TEAD degrader-1 relies on CRBN and the proteasome system for TEAD2 degradation; disruption of CRBN binding attenuates this activity. PROTAC TEAD degrader-1 decreases expression of YAP target genes CYR61 and CTGF. PROTAC TEAD degrader-1 can be used for the research of NF2-deficient cancer .

HY-P1727

Super-TDU 5+ Cited Publications	YAP	Cancer
Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model .

HY-155310

AF-2112	YAP	Cancer
AF-2112 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2.

HY-155309

LM-41	YAP	Cancer
LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2. LM-41 inhibits migration of human MDA-MB-231 breast cancer cells .

HY-147208

MSC-4106	YAP	Cancer
MSC-4106 is an orally active and potent inhibitor of YAP/TAZ-TEAD. MSC-4106 inhibits TEAD1 or TEAD3 auto-palmitoylation and shows inhibitory effect on NCI-H226 tumor xenograft model .

HY-179505

OPN-9652	YAP	Cancer
OPN-9652 is a potent, orally active, and covalent TEAD inhibitor (MSTO-211H TEAD IC₅₀ = 0.005 µM) targeting the central palmitate binding pocket of TEADs. OPN-9652 reduces TEAD-dependent reporter activity and expression of TEAD targets (CTGF and CYR61). OPN-9652 resensitizes drug-tolerant SOX10 KO cells to BRAFi + MAPKi. OPN-9652 delays the onset of tumor resistance to BRAFi + MEKi from minimal residual disease (MRD) in a BRAF mutant A375 xenograft mouse model. OPN-9652 can be used for melanoma research .

HY-168704

YAP/TAZ-TEAD-IN-2	YAP TAM Receptor Survivin	Cancer
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that inhibits the interaction between YAP/TAZ and TEAD. YAP/TAZ-TEAD-IN-2 suppresses the transcriptional activity of TEAD, with an IC₅₀ of 1.2 nM. YAP/TAZ-TEAD-IN-2 inhibits YAP/TAZ-TEAD target genes expression (Cyr61, CTGF, AXL and Survivin) and breast cancer cell proliferation .

HY-179440

EA-C15	YAP	Cancer
EA-C15 is a potent and selective TEAD inhibitor with an IC₅₀ of 0.34 μM. EA-C15 covalently binds to the TEAD palmitoylation site, blocks palmitoylation and transcriptional activity, and inhibits YAP-dependent cancer cell proliferation and YAP-TEAD target gene (CTGF and CYR61) transcription. EA-C15 can be used for cancer research .

HY-159912

pan-TEAD-IN-1	YAP	Cancer
pan-TEAD-IN-1 (Compound 3) is an orally active pan-TEAD inhibitor targeting the palmitoylation site of TEAD, disrupting its interaction with the coactivators YAP/TAZ, thereby suppressing the transcriptional upregulation of oncogenes (e.g., Ctgf and *Cyr61) in the Hippo* signaling pathway. pan-TEAD-IN-1 exhibits excellent activity with a luciferase IC₅₀ of 0.36 nM and an H226 cell IC₅₀ of 1.52 nM. It also shows favorable pharmacokinetics (AUC_0–∞ = 228.7 μg/mL·min, T_1/2 = 183.9 min). In TEAD-dependent xenograft mouse models, pan-TEAD-IN-1 significantly inhibited tumor growth, showing promise for research in TEAD-dependent cancers .

HY-162012

HC-258	YAP	Cancer
HC-258 (compound 26) binds with the cysteine in TEAD’s PA pocket. HC-258 reduces the CTGF, CYR61, AXL, and NF2 transcript levels and inhibits the migration of MDA-MB-231 breast cancer cells .

HY-168085

CV-4-26	YAP Apoptosis	Cancer
CV-4-26 (Compound 22) is a covalent inhibitor of TEAD. CV-4-26 inhibits YAP/TEAD-based transcription, leading to the reduction of CTGF and CYR61 expression. CV-4-26 inhibits Huh7 and HepG2 cell colony formation, induces cell cycle arrest, and apoptosis. CV-4-26 shows antitumor activity against hepatocellular carcinoma (HCC) and hepatoblastoma (HB) .

HY-179559

OPN-9643	YAP	Cancer
OPN-9643 is a covalent inhibitor targeting the central palmitate binding pocket of TEADs with an IC₅₀ of 15 nM, preventing autopalmitoylation and reducing TEAD-driven luciferase activity and canonical TEAD targets, CTGF and CYR61. OPN-9643 can be used for the research of cancer, such as melanoma .

HY-RS02110

CCN1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCN1 Human Pre-designed siRNA Set A CCN1 Human Pre-designed siRNA Set A

HY-P1727A

Super-TDU TFA	YAP	Cancer
Super-TDU TFA is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU TFA suppresses tumor growth in gastric cancer mouse model .

HY-RS24420

Ccn1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccn1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccn1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccn1 Rat Pre-designed siRNA Set A Ccn1 Rat Pre-designed siRNA Set A

HY-RS17949

Ccn1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccn1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccn1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccn1 Mouse Pre-designed siRNA Set A Ccn1 Mouse Pre-designed siRNA Set A

Cat. No.	Nombre del producto	Target	Research Area

HY-P1727

Super-TDU 5+ Cited Publications	YAP	Cancer
Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model .

HY-P1727A

Super-TDU TFA	YAP	Cancer
Super-TDU TFA is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU TFA suppresses tumor growth in gastric cancer mouse model .

Cat. No.	Nombre del producto	Target	Research Area	Image

HY-P990396

*Anti-CYR61/CCN1 Antibody*	Inhibitory Antibodies	Inflammation/Immunology
Anti-CYR61/CCN1 Antibody is a CHO-expressed human antibody that targets *CYR61/CCN1. The Anti-CYR61/CCN1* Antibody contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CYR61/CCN1 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species:	Human (1) Mouse (1)
Tag:	His (1) Fc (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Nombre del producto	Species	Source	Image

HY-P7842

	*CCN1/Cyr61* Protein, Human (HEK293, Fc)** 2 Publications Verification rHuCCN family member 1/Cyr61, Fc; Protein Cyr61; CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10 ; GIG1; Cyr61; CCN1; IGFBP10;	Human	HEK293
	CCN1/Cyr61 proteins play critical roles in cellular processes, promoting cell proliferation, chemotaxis, angiogenesis, and adhesion. It coordinates wound healing by upregulating key genes related to angiogenesis, inflammation and matrix remodeling in skin fibroblasts and is heparin binding dependent. CCN1/Cyr61 Protein, Human (HEK293, Fc) is the recombinant human-derived CCN1/Cyr61 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704010

	*CCN1/Cyr61* Protein, Mouse (His)** 1 Publications Verification sCcn1; Cyr61; Igfbp10; CCN family member 1; 3CH61; Cellular communication network factor 1; Cysteine-rich angiogenic IGFBP-10; Protein Cyr61; inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10	Mouse	E. coli
	CCN1/Cyr61 Protein, Mouse (His) is the recombinant mouse-derived CCN1/Cyr61 protein, expressed by E. coli, with N-10*His tag.

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HY-P86830

	CYR61/CCN1 Antibody (YA6523) 3CH61 antibody; CCN 1 antibody; CCN family member 1 antibody; CCN1 antibody; Cyr 61 antibody; Cyr61 antibody; Cyr61 protein antibody; Cyr61_HUMAN antibody; Cysteine rich angiogenic inducer 61 antibody; Cysteine rich heparin binding protein 61 antibody; 3CH61 antibody; CCN 1 antibody; CCN family member 1 antibody; CCN1 antibody; Cyr 61 antibody; Cyr61 antibody; Cyr61 protein antibody; Cyr61_HUMAN antibody; Cysteine rich angiogenic inducer 61 antibody; Cysteine rich heparin binding protein 61 antibody; Cysteine-rich angiogenic inducer 61 antibody; GIG 1 antibody; GIG1 antibody; IBP-10 antibody; IGF-binding protein 10 antibody; Igfbp 10 antibody; IGFBP-10 antibody; Igfbp10 antibody; Insulin like growth factor binding protein 10 antibody; Insulin-like growth factor-binding protein 10 antibody; Protein Cyr61 antibody; Protein GIG1 antibody;	WB, ICC/IF, IHC-P, IF-Tissue	Human
	CYR61/CCN1 Antibody (YA6523) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CYR61/CCN1.

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Cat. No.	Nombre del producto		Classification

HY-RS02110

CCN1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24420

Ccn1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ccn1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccn1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17949

Ccn1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ccn1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccn1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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