YAP/TAZ-TEAD-IN-2
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that inhibits the interaction between YAP/TAZ and TEAD. YAP/TAZ-TEAD-IN-2 suppresses the transcriptional activity of TEAD, with an IC50 of 1.2 nM. YAP/TAZ-TEAD-IN-2 inhibits YAP/TAZ-TEAD target genes expression (Cyr61, CTGF, AXL and Survivin) and breast cancer cell proliferation.
For research use only. We do not sell to patients.
- Formula: C19H20N2O3S
- Molecular Weight:356.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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YAP/TAZ-TEAD |
YAP/TAZ-TEAD-IN-2 (2.5-20 μM, 72 h) dose-dependently inhibits MDA-MB-231 cells proliferation with IC50 of 4.4 μM[1].
YAP/TAZ-TEAD-IN-2 (1-10 μM, 48 h) inhibits the expression of four major YAP/TAZ-TEAD target proteins, i.e., Cyr61, CTGF, AXL and BIRC5 (Survivin) in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:2.5, 5, 10, 20 μM
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Incubation Time:72 h
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Result:Dose-dependently inhibited MDA-MB-231 cells proliferation with IC50 of 4.4 μM.
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Cell Line:MDA-MB-231 cells
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Concentration:1, 5, 10 μM
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Incubation Time:48 h
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Result:Dose-dependently inhibited the four principal YAP/TAZ-TEAD target proteins, namely Cyr61, CTGF, AXL and BIRC5 (Survivin).
Chemical Information
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Molecular Weight 356.44
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Formula C19H20N2O3S
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SMILES
O=S(NCCN(C=C1)C(C1=C2)=CC=C2OCC3=CC=CC=C3)(C=C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YAP/TAZ-TEAD-IN-2 Related Classifications
HY-168704 Related Classifications
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