2. Stem Cell/Wnt
  3. YAP
  4. OPN-9652

OPN-9652 is a potent, orally active, and covalent TEAD inhibitor (MSTO-211H TEAD IC50 = 0.005 µM) targeting the central palmitate binding pocket of TEADs. OPN-9652 reduces TEAD-dependent reporter activity and expression of TEAD targets (CTGF and CYR61). OPN-9652 resensitizes drug-tolerant SOX10 KO cells to BRAFi + MAPKi. OPN-9652 delays the onset of tumor resistance to BRAFi + MEKi from minimal residual disease (MRD) in a BRAF mutant A375 xenograft mouse model. OPN-9652 can be used for melanoma research.

For research use only. We do not sell to patients.

OPN-9652

OPN-9652 Chemical Structure

CAS No. : 2866423-35-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

OPN-9652 Related Antibodies

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YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

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Description

OPN-9652 is a potent, orally active, and covalent TEAD inhibitor (MSTO-211H TEAD IC50 = 0.005 µM) targeting the central palmitate binding pocket of TEADs. OPN-9652 reduces TEAD-dependent reporter activity and expression of TEAD targets (CTGF and CYR61). OPN-9652 resensitizes drug-tolerant SOX10 KO cells to BRAFi + MAPKi. OPN-9652 delays the onset of tumor resistance to BRAFi + MEKi from minimal residual disease (MRD) in a BRAF mutant A375 xenograft mouse model. OPN-9652 can be used for melanoma research[1].

IC50 & Target[1]

TEAD

0.005 μM (IC50)

Molecular Weight

365.32

Formula

C19H15F4NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=CC(N1CC2=C(C=CC(OC3=CC=C(C(F)(F)F)C(F)=C3)=C2)CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (95.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7373 mL 13.6866 mL 27.3733 mL
5 mM 0.5475 mL 2.7373 mL 5.4747 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7373 mL 13.6866 mL 27.3733 mL 68.4332 mL
5 mM 0.5475 mL 2.7373 mL 5.4747 mL 13.6866 mL
10 mM 0.2737 mL 1.3687 mL 2.7373 mL 6.8433 mL
15 mM 0.1825 mL 0.9124 mL 1.8249 mL 4.5622 mL
20 mM 0.1369 mL 0.6843 mL 1.3687 mL 3.4217 mL
25 mM 0.1095 mL 0.5475 mL 1.0949 mL 2.7373 mL
30 mM 0.0912 mL 0.4562 mL 0.9124 mL 2.2811 mL
40 mM 0.0684 mL 0.3422 mL 0.6843 mL 1.7108 mL
50 mM 0.0547 mL 0.2737 mL 0.5475 mL 1.3687 mL
60 mM 0.0456 mL 0.2281 mL 0.4562 mL 1.1406 mL
80 mM 0.0342 mL 0.1711 mL 0.3422 mL 0.8554 mL
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OPN-9652 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OPN-96522866423-35-8OPN9652OPN 9652YAPYes-associated proteinCTGFCYR61SOX10 KO cellsBRAFiMAPKiminimal residual diseaseBRAF mutant A375 xenograft mouse modelmelanomaInhibitorinhibitorinhibit

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