OPN-9652
Based on 1 Customer Validation
OPN-9652 is a potent, orally active, and covalent TEAD inhibitor (MSTO-211H TEAD IC50 = 0.005 µM) targeting the central palmitate binding pocket of TEADs. OPN-9652 reduces TEAD-dependent reporter activity and expression of TEAD targets (CTGF and CYR61). OPN-9652 resensitizes drug-tolerant SOX10 KO cells to BRAFi + MAPKi. OPN-9652 delays the onset of tumor resistance to BRAFi + MEKi from minimal residual disease (MRD) in a BRAF mutant A375 xenograft mouse model. OPN-9652 can be used for melanoma research.
For research use only. We do not sell to patients.
- Purity: 98.84%
- CAS No.: 2866423-35-8
- Formula: C19H15F4NO2
- Molecular Weight:365.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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TEAD 0.005 μM (IC50) |
Chemical Information
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CAS No. 2866423-35-8
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Appearance Solid
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Molecular Weight 365.32
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Formula C19H15F4NO2
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Color White to off-white
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SMILES
C=CC(N1CC2=C(C=CC(OC3=CC=C(C(F)(F)F)C(F)=C3)=C2)CC1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 35 mg/mL (95.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7373 mL | 13.6866 mL | 27.3733 mL | 68.4332 mL |
| 5 mM | 0.5475 mL | 2.7373 mL | 5.4747 mL | 13.6866 mL | |
| 10 mM | 0.2737 mL | 1.3687 mL | 2.7373 mL | 6.8433 mL | |
| 15 mM | 0.1825 mL | 0.9124 mL | 1.8249 mL | 4.5622 mL | |
| 20 mM | 0.1369 mL | 0.6843 mL | 1.3687 mL | 3.4217 mL | |
| 25 mM | 0.1095 mL | 0.5475 mL | 1.0949 mL | 2.7373 mL | |
| 30 mM | 0.0912 mL | 0.4562 mL | 0.9124 mL | 2.2811 mL | |
| 40 mM | 0.0684 mL | 0.3422 mL | 0.6843 mL | 1.7108 mL | |
| 50 mM | 0.0547 mL | 0.2737 mL | 0.5475 mL | 1.3687 mL | |
| 60 mM | 0.0456 mL | 0.2281 mL | 0.4562 mL | 1.1406 mL | |
| 80 mM | 0.0342 mL | 0.1711 mL | 0.3422 mL | 0.8554 mL |
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