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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
DNA religation
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "DNA religation" in MCE Product Catalog:
186
Target:
Research Areas:
Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.
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81 Cited Publications
Cat. No.: HY-16562
CAS No.: 97682-44-5
Synonyms: (+)-Irinotecan; CPT-11; VAL-413free base
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Research Areas:
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
Cat. No.: HY-16562S1
CAS No.: 718612-62-5
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HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8 .
Cat. No.: HY-13630A
CAS No.: 122405-33-8
Synonyms: BMY-40481 disodium
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Research Areas:
Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy.
Cat. No.: HY-131438
CAS No.: 149809-18-7
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GI-149893 is a selective topoisomerase I (TopoI) inhibitor. GI-149893 prevents DNA religation and induces irreversible DNA damage in tumor cells. GI-149893 is promising for research of cancers (e.g., colon carcinoma HT-29/SW-48, breast MX-1, prostate PC-3 xenografts) .
Cat. No.: HY-16560B
CAS No.: 110351-92-3
Synonyms: (R)-Campathecin; (R)-(+)-Camptothecin; (R)-CPT
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(R)-Camptothecin is an enantiomer of Camptothecin (CPT), is inactive as an inhibitor of the DNA religation reaction and consequently do not poison Top1 .
Cat. No.: HY-16562S
CAS No.: 718613-28-6
Synonyms: (+)-Irinotecan-d10; CPT-11-d10; VAL-413-d10free base
Cat. No.: HY-16562R
CAS No.: 97682-44-5
Synonyms: (+)-Irinotecan (Standard); CPT-11 (Standard); VAL-413free base (Standard)
Research Areas:
Irinotecan (Standard) is the analytical standard of Irinotecan. This product is intended for research and analytical applications. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
Cat. No.: HY-172229
CAS No.: 1227303-03-8
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NBTI 5463 is a bacterial type II topoisomerases (topoisomerase II) inhibitor with antibacterial activity. NBTI 5463 inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. NBTI 5463 binds to topoisomerase II to prevent DNA cleavage and religation, inhibiting bacterial DNA replication and transcription. NBTI 5463 is promising for research of Gram-negative bacterial infection .
Cat. No.: HY-13630R
CAS No.: 117091-64-2
Synonyms: BMY-40481 (Standard)
Research Areas:
Etoposide phosphate (Standard) is the analytical standard of Etoposide phosphate. This product is intended for research and analytical applications. Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.
Cat. No.: HY-16562S2
CAS No.: 718613-65-1
Synonyms: (+)-Irinotecan-13C6; CPT-11-13C6; VAL-413-13C6 free base
Cat. No.: HY-182748
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Research Areas:
NL-26 is a Topoisomerase I inhibitor. NL-26 stabilizes the covalent Topoisomerase I (Topo I)-DNA complex, prevents DNA religation and triggers the DNA damage response. NL-26 induces G2/M cell cycle arrest and apoptosis in cancer cells. NL-26 can be used for the research of colorectal cancer .
Cat. No.: HY-107485R
CAS No.: 1568-80-5
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Research Areas:
HIV-1 integrase inhibitor 8 (Standard) is the analytical standard of HIV-1 integrase inhibitor 8 (HY-107485). This product is intended for research and analytical applications. HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8 .
Cat. No.: HY-184749
Target:
Research Areas:
Topoisomerase I-IN-24 (compound 5l) is a topoisomerase I (topoisomerase I) inhibitor. Topoisomerase I-IN-24 inhibits topoisomerase I activity in a concentration-dependent manner, suppresses cancer cell migration, induces apoptosis (apoptosis), and arrests the cell cycle at the G1 phase. Topoisomerase I-IN-24 can be used in the research of lung cancer, hepatocellular carcinoma and cervical adenocarcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
