1. Metabolic Enzyme/Protease
  2. HIV Integrase
  3. HIV-1 integrase inhibitor 8

HIV-1 integrase inhibitor 8 

Cat. No.: HY-107485
Handling Instructions

HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8.

For research use only. We do not sell to patients.

HIV-1 integrase inhibitor 8 Chemical Structure

HIV-1 integrase inhibitor 8 Chemical Structure

CAS No. : 1568-80-5

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Description

HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1].

In Vitro

HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 µM[1].
The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays[1].
HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells[1].

Molecular Weight

308.41

Formula

C₂₁H₂₄O₂

CAS No.

1568-80-5

SMILES

CC1(CC(C2=CC(O)=CC=C21)(C3)C4=CC(O)=CC=C4C3(C)C)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

HIV-1 integrase inhibitor 8HIV IntegraseIntegraseHIV-1cationiccofactorHeLacellsstrand-transferDNA religationInhibitorinhibitorinhibit

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HIV-1 integrase inhibitor 8
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