149809-18-7
Chemical Structure
GI-149893
- CAS No.: 149809-18-7
- Formula:C27H28N4O6
- Molecular Weight:504.53
IUPAC Name: (S)-7-ethyl-7-hydroxy-14-((4-methylpiperazin-1-yl)methyl)-10,13-dihydro-11H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(7H)-dione
InChIKey: HMYGIAFIUNLLIK-MHZLTWQESA-N
SMILES: O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CN5CCN(C)CC5)C6=CC7=C(OCO7)C=C6N=C4C3=C2)=O
Biological Activity: GI-149893 is a selective topoisomerase I (TopoI) inhibitor. GI-149893 prevents DNA religation and induces irreversible DNA damage in tumor cells. GI-149893 is promising for research of cancers (e.g., colon carcinoma HT-29/SW-48, breast MX-1, prostate PC-3 xenografts)[1][2].
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GI-149893 | GI-149893 is a selective topoisomerase I (TopoI) inhibitor. GI-149893 prevents DNA religation and induces irreversible DNA damage in tumor cells. GI-149893 is promising for research of cancers (e.g., colon carcinoma HT-29/SW-48, breast MX-1, prostate PC-3 xenografts). | |||||||||||||||||||||
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References
- [1]. Emerson DL, et al. In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues. Cancer Res. 1995 Feb 1;55(3):603-9. [Content Brief]
- [2]. Fan Y, et al. Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin. J Med Chem. 1998 Jun 18;41(13):2216-26. [Content Brief]
