2 Results for "

DS3939

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "DS3939" in MCE Product Catalog:

1
Gatipotuzumab
Gatipotuzumab
0 Images
1 Cited Publications
Cat. No.: HY-P99634
CAS No.: 1264737-26-9
Synonyms: PankoMab; DS-3939a antibody

Target:  

Mucin

Research Areas:  

Cancer

Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC) .
loading...
    loading...
View All Sizes
DS-3939a
DS-3939a
0 Images
Cat. No.: HY-177442
Synonyms: DS-3939
DS-3939a (DS-3939) is an anti-TA-MUC1 (tumor-associated mucin-1) antibody-drug conjugate (ADC). DS-3939a consists of a humanized anti-TA-MUC1 IgG1 monoclonal antibody Gatipotuzumab ( HY-P99634), a stable and cleavable tetrapeptide-based linker (Gly-Gly-Phe-Gly), and a DNA topoisomerase I inhibitor payload (DXd) (HY-13631D), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). DS-3939a inhibits the growth of TA-MUC1-positive cancer cells (CFPAC-1, NCI-H2110) by inducing DNA damage and apoptosis. DS-3939a exhibits significant antitumor activity in a variety of TA-MUC1-expressing advanced solid tumors. DS-3939a can be used for the study of TA-MUC1-expressing advanced cancers .
loading...
    loading...
View All Sizes
Assay Types