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14 Results for "
DUBA
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "DUBA" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: Duocarmazine
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Vc-seco-DUBA (Duocarmazine) is a agent-linker conjugate for ADC with potent antitumor activity by using DUBA (DNA alkylating agent), linked via the ADC linker Vc-seco .
Cat. No.: HY-P99101
CAS No.: 2490556-50-6
Synonyms: AEX-4089; MGC026 antibody
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Seco-DUBA hydrochloride is a DNA-targeting cytotoxic agent. Seco-DUBA hydrochloride binds to the minor groove of A-T-rich DNA regions, alkylates the adenine N3 residue, and undergoes spontaneous spirocyclization to generate active DUBA (HY-160969). Seco-DUBA hydrochloride exerts cytotoxic activity against human cancer cells. The reduced hydrophobicity of Seco-DUBA hydrochloride supports the development of antibody-drug conjugates .
Cat. No.: HY-132180
CAS No.: 1795733-93-5
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Seco-DUBA hydrochloride is a toxin for ADC drug SYD985 .
Cat. No.: HY-131085
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Desmethyl Vc-seco-DUBA consists a cleavable ADC linker (Desmethyl Vc-seco) and a DNA alkylating agent (DUBA). Desmethyl Vc-seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs) .
Cat. No.: HY-145636
CAS No.: 2490556-51-7
Synonyms: AEX4089DC1; MGC018
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Vobramitamab duocarmazine (AEX4089DC1; MGC018), a humanized antibody-drug conjugate (ADC) targeted against B7-H3 (CD276). Vobramitamab duocarmazine is comprised of the cleavable linker-Duocarmycin payload, Vc-seco-DUBA (HY-128957), conjugated to an anti-B7-H3 humanized IgG1κ monoclonal antibody. Vobramitamab duocarmazine has antineoplastic activity .
Cat. No.: HY-RS09874
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OTUD5 Human Pre-designed siRNA Set A contains three designed siRNAs for OTUD5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19225
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Otud5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Otud5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-160969
CAS No.: 1642147-15-6
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DUBA is a toxin compound that acts on DNA, exhibiting alkylating activity. DUBA is an ADC payload that can be coupled with monoclonal antibodies to synthesize antibody-drug conjugates (ADCs) .
Cat. No.: HY-P701483
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: OTUD5; OTU domain-containing protein 5; Deubiquitinating enzyme A; DUBA
Cat. No.: HY-P701484
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: OTUD6A; OTU domain-containing protein 6A; DUBA-2
Cat. No.: HY-P701482
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: YOD1; Ubiquitin thioesterase OTU1; DUBA-8; HIV-1-induced protease 7; HIN-7; HsHIN7; OTU domain-containing protein 2
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
