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Cat. No.: HY-132180

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Seco-DUBA hydrochloride

Seco-DUBA hydrochloride is a toxin for ADC drug SYD985.

For research use only. We do not sell to patients.

CAS No.: 1795733-93-5
Formula: C₂₉H₂₃ClN₄O₄.xHCl

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Seco-DUBA hydrochloride Chemical Structure

CAS No.: 1795733-93-5

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Biological Activity

Description

Seco-DUBA hydrochloride is a toxin for ADC drug SYD985^[1].

All ADC Payloads Isoforms :

Chemical Information

CAS No. 1795733-93-5
Formula C₂₉H₂₃ClN₄O₄.xHCl
SMILES

ClC[C@H]1C2=C(C=C(C3=CC=CC(C)=C32)O)N(C1)C(C4=CN(C=C(C=C5)NC(C6=CC=C(C=C6)O)=O)C5=N4)=O.Cl[H].[x]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ronald C Elgersma, et al. Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985. Mol Pharm. 2015 Jun 1;12(6):1813-35. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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Seco-DUBA hydrochloride

All ADC Payloads Isoforms