Spiro-duocarmycin
Spiro-duocarmycin is a DNA minor groove N3-adenine alkylating agent. Spiro-duocarmycin exerts cytotoxic effects via DNA alkylation. Spiro-duocarmycin is the active spirocyclized form of seco-DUBA, which is incorporated as an inactive prodrug into the linker-drug construct of antibody-drug conjugates (ADCs). DUBA serves as an ADC payload that can be conjugated with monoclonal antibodies to synthesize antibody-drug conjugates (ADCs).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 1642147-15-6
- 화학식: C29H22N4O4
- 분자량:490.51
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
Spiro-duocarmycin (DUBA; Compound 3b) potently inhibits the viability of human breast cancer SK-BR-3 cells, with an IC50 of 0.07 nM, and its efficacy is comparable to that of its precursor seco-DUBA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | CL |
|---|---|---|---|---|
| Rat[1] | 0.083 mg/kg | i.v. | 1.1 h | 17 L/h/kg |
Chemical Information
-
CAS No. 1642147-15-6
-
분자량 490.51
-
화학식 C29H22N4O4
-
SMILES
O=C(C1=CN2C(C=CC(NC(C3=CC=C(C=C3)O)=O)=C2)=N1)N4C([C@@]5(C6=C(C)C=CC=C67)[C@](C4)([H])C5)=CC7=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Spiro-duocarmycin Related Classifications
HY-160969 Related Classifications
Powered by Bioz