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DesE_B

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By Targets:	Drug Derivative (1) Interleukin Related (1) NF-κB (1) TNF Receptor (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1)

Targets Recommended: Dihydroceramide Desaturase 1 (DES1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Doxorubicinone 2 Publications Verification Adriamycin aglycone; Adriamycinone	NF-κB TNF Receptor Interleukin Related Drug Derivative	Inflammation/Immunology Cancer
Doxorubicinone (Adriamycin aglycone) is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research .

Doxorubicinone 2 Publications Verification Adriamycin aglycone; Adriamycinone	Quinones Structural Classification Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	NF-κB TNF Receptor Interleukin Related Drug Derivative
Doxorubicinone (Adriamycin aglycone) is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research .

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