37 Results for "

ECD

" in MedChemExpress (MCE) Product Catalog:
Products (37)

37 Results for "ECD" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99380
CAS No.: 2169946-15-8
Synonyms: ZW 25; ZW-49 Antibody

Target:  

EGFR

Research Areas:  

Cancer

Zanidatamab (ZW25) is a humanised, bispecific monoclonal antibody targeting 2 distinct HER2 epitopes (ECD2 and ECD4). Zanidatamab has anti-tumour activity .
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1
1 Cited Publications
Cat. No.: HY-18377
CAS No.: 1420071-30-2
Synonyms: DR5 Activator
Target:  

TNF Receptor Apoptosis

Research Areas:  

Cancer

Bioymifi (DR5 Activator), a potent TRAIL receptor DR5 activator, binds to the extracellular domain (ECD) of DR5 with a Kd of 1.2 μM. Bioymifi can act as a single agent to induce DR5 clustering and aggregation, leading to apoptosis .
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Cat. No.: HY-P990957
CAS No.: 2764727-44-6
Synonyms: BCA-101; FMAB2

Target:  

EGFR TGF-beta/Smad

Research Areas:  

Inflammation/Immunology Cancer

Ficerafusp alfa (BCA-101) is a bispecific antibody targeting EGFR and TGFβ, with a Kd of 2.58 nM against EGFR and a Kd of 61.3 nM against TGFβ1. Ficerafusp alfa binds to EGFR, inhibits EGFR phosphorylation, blocks EGF-dependent cell proliferation, and mediates antibody-dependent cellular cytotoxicity against EGFR-positive tumor cells. Ficerafusp alfa sequesters TGFβ via its TGFβRII ECD domain, neutralizes the activity of TGFβ and TGFβ1, and blocks TGFβ-dependent processes, including epithelial-mesenchymal transition, cell invasion, and differentiation of inducible regulatory T cells. Ficerafusp alfa is applicable to research related to head and neck squamous cell carcinoma, advanced solid tumors, squamous non-small cell lung cancer, anal squamous cell carcinoma, colorectal cancer, and pancreatic cancer .
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Cat. No.: HY-P10495A
Target:  

Peptides

Research Areas:  

Cancer

GPR110 peptide agonist P12 acetate is the acetate salt form of GPR110 peptide agonist P12 (HY-P10495). GPR110 peptide agonist P12 acetateis a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 acetate can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 acetate mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 acetate can be used in the study of developmental disorders and cancers related to GPR110 .
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Cat. No.: HY-P99912
CAS No.: 2250261-27-7
Synonyms: AMG-673

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Emerfetamab is an anti-CD3E/CD33 monoclonal antibody .
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Cat. No.: HY-P990903
CAS No.: 2577961-36-3
Synonyms: YMS-5A

Target:  

CD3

Research Areas:  

Inflammation/Immunology

HY-P990903 is an CD3E/CD33-targeting [H-γ1 _ L-κ-scFv heavy -κ]-dimer type bispecific antibody .
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Cat. No.: HY-P991443

Target:  

CD73

Research Areas:  

Cancer

IPH5301 is a human IgG1 monoclonal antibody (mAb) targeting NT5E/CD73. IPH5301 has a functionally silent Fc domain, specifically inhibits soluble and membrane CD73 enzyme activity, and restores the proliferation of immune T cells. IPH5301 can be used in anti-tumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P10495
CAS No.: 1778685-49-6
Research Areas:  

Others Cancer

GPR110 peptide agonist P12 is a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 can be used in the study of developmental disorders and cancers related to GPR110 .
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Cat. No.: HY-P991572
CAS No.: 1399724-72-1

Target:  

EGFR

Research Areas:  

Cancer

MM-151 is a humanized IgG1 monoclonal antibody targeting EGFR. MM-151 binds multiple regions of the EGFR extracellular domain (ECD) and reduces its mutations in circulating cell-free tumor DNA with EGFR resistance. MM-151 significantly inhibits EGFR signaling and cell growth. MM-151 can be used for drug-resistant cancers research, such as colorectal, non-small cell lung and triple negative breast cancer .
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Cat. No.: HY-P99963
CAS No.: 2387417-06-1
Synonyms: HS636

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment .
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Cat. No.: HY-P991332

Target:  

CD73

Research Areas:  

Cancer

JAB-BX102 is a human monoclonal antibody (mAb) targeting NT5E/CD73. JAB-BX102 can be used in the study of cancers such as breast cancer, pancreatic cancer, and prostate cancer .
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Cat. No.: HY-P991330

Target:  

CD73

Research Areas:  

Cancer

BMS-986179 is a human monoclonal antibody (mAb) targeting NT5E/CD73. BMS-986179 inhibits CD73 enzymatic activity in tumor vasculature and tumor cells. BMS-986179 can be used in advanced solid tumors research .
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Cat. No.: HY-RS04132
Research Areas:  

Others

ECD Human Pre-designed siRNA Set A contains three designed siRNAs for ECD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P991239

Target:  

EGFR

Research Areas:  

Cancer

NM-02 is an antibody targeting HER2 with an EC50 value of 1.2 nM. NM-02 binds to domains I and II of HER2-ECD, blocking HER2-related signaling pathways. NM-02 is promising for research of HER2-positive breast cancer .
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Cat. No.: HY-P991331

Target:  

CD73

Research Areas:  

Cancer

BC-010 is a human monoclonal antibody (mAb) targeting NT5E/CD73. BC-010 can be used in the study of tumors.
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Cat. No.: HY-RS12649
Research Areas:  

Others

SEM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SEM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P991465

Target:  

TNF Receptor

Research Areas:  

Cancer

Anti-CD27 Antibody (M2177) is a human monoclonal antibody (mAb) targeting TNFRSF7/CD27. Anti-CD27 Antibody (M2177) inhibits the binding of sCD70 to human CD27 ECD-Fc. Anti-CD27 Antibody (M2177) can be used in the study of anti-tumor immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P991466

Target:  

TNF Receptor

Research Areas:  

Cancer

Anti-CD27 Antibody (M2191) is a human monoclonal antibody (mAb) targeting TNFRSF7/CD27. Anti-CD27 Antibody (M2191) inhibits the binding of sCD70 to human CD27 ECD-Fc. Anti-CD27 Antibody (M2191) can be used in the study of anti-tumor immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-RS17935
Research Areas:  

Others

Ecd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ecd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS24405
Research Areas:  

Others

Ecd Rat Pre-designed siRNA Set A contains three designed siRNAs for Ecd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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