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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
EMT6 TNBC cells
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "EMT6 TNBC cells" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-171658
CAS No.: 3070346-91-4
Research Areas:
R1-ICR-5 is a highly selective RIPK1 PROTAC degrader. Mediated by VHL, R1-ICR-5 induces the degradation of RIPK1, which in turn dysregulates the TNFR1 and TLR3/4 signaling hubs, enhances the signaling outputs of NF-κB, MAPK and IFN, and simultaneously promotes RIPK3 activation and necroptosis (necroptosis). R1-ICR-5 can be used in the research of triple-negative breast cancer and skin inflammation .
Cat. No.: HY-150609
CAS No.: 2924036-87-1
Target:
Research Areas:
SHP2/CDK4-IN-1 (compound 10) is an orally active and potent SHP2 and CDK4 dual inhibitor, with IC50 values of 4.3 and 18.2 nM, respectively. SHP2/CDK4-IN-1 effectively induces G0/G1 arrest to prevent the proliferation of TNBC cell lines. SHP2/CDK4-IN-1 shows significant antitumor efficacy in the EMT6 syngeneic mouse model. SHP2/CDK4-IN-1 can be used for triple-negative breast cancer (TNBC) research .
Cat. No.: HY-184268
Pim-1 kinase-IN-17 is a non-orthosteric inhibitor of PIM-1 onco-protein. Pim-1 kinase-IN-17 physically interacts with PIM-1 via a non-orthosteric binding site (Kd of 1.38 μM), does not inhibit PIM-1 kinase function, and decreases PIM-1 concentration under cellular conditions. Pim-1 kinase-IN-17 reduces tumor burden. Pim-1 kinase-IN-17 can be used for the research of triple-negative breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
