3070346-91-4
Chemical Structure
R1-ICR-5
- CAS No.: 3070346-91-4
- Formula:C54H70N8O7S2
- Molecular Weight:1007.31
InChIKey: KVDLSQZBDWJNSG-VINRIKPSSA-N
SMILES: O=C(OC1CCCCC1)NC2=CC(C3=CC=C4N=C(NC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=O)SC4=C3)=CN=C2C
Biological Activity: R1-ICR-5 is a highly selective RIPK1 PROTAC degrader. Mediated by VHL, R1-ICR-5 induces the degradation of RIPK1, which in turn dysregulates the TNFR1 and TLR3/4 signaling hubs, enhances the signaling outputs of NF-κB, MAPK and IFN, and simultaneously promotes RIPK3 activation and necroptosis (necroptosis). R1-ICR-5 can be used in the research of triple-negative breast cancer and skin inflammation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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R1-ICR-5 | 98.73% | R1-ICR-5 is a highly selective RIPK1 PROTAC degrader. Mediated by VHL, R1-ICR-5 induces the degradation of RIPK1, which in turn dysregulates the TNFR1 and TLR3/4 signaling hubs, enhances the signaling outputs of NF-κB, MAPK and IFN, and simultaneously promotes RIPK3 activation and necroptosis (necroptosis). R1-ICR-5 can be used in the research of triple-negative breast cancer and skin inflammation. | ||||||||||||||||||||
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