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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
G-rich
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "G-rich" in MCE Product Catalog:
hVEGF-IN-1, a quinazoline derivative, could specifically bind to the G-rich sequence in the internal ribosome entry site A (IRES-A) and destabilize the G-quadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM in SPR experiments. hVEGF-IN-1 could hinder tumor cells migration and repress tumor growth by decreasing VEGF-A protein expression .
Cat. No.: HY-148947
CAS No.: 182873-67-2
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Cy5 Phosphoramidite is a fluorescent labeling reagent . Cy5 Phosphoramidite serves as a fluorescent tag for 3' terminal labeling of single-stranded DNA, enabling fluorescence-based nucleic acid detection, monitoring, quantification, and in vitro study .
Cat. No.: HY-120102
CAS No.: 1422423-23-1
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Emicoron is a new promising G4 ligand and bind G-rich oncogene promoters. Emicoron possesses a marked antitumoral activity? alone or in combination with chemotherapeutics in vivo. Emicoron can be used for cancer research .
Cat. No.: HY-P83210A
Synonyms: G-rich sequence factor 1
Cat. No.: HY-101931R
CAS No.: 1637443-98-1
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hVEGF-IN-1 (Standard) is the analytical standard of hVEGF-IN-1 (HY-101931). This product is intended for research and analytical applications. hVEGF-IN-1, a quinazoline derivative, could specifically bind to the G-rich sequence in the internal ribosome entry site A (IRES-A) and destabilize the G-quadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM in SPR experiments. hVEGF-IN-1 could hinder tumor cells migration and repress tumor growth by decreasing VEGF-A protein expression .
Cat. No.: HY-185721
CAS No.: 25191-14-4
Synonyms: Polyguanylic acid
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Poly (G) (Polyguanylic acid) is a high-molecular-weight synthetic ribopolynucleotide. In the presence of Na + or K + ions, Poly (G) undergoes time-dependent structural modification, gradually self-assembling from a single strand into large G-quadruplex aggregates. Poly (G) undergoes cooperative secondary structure dissociation under alkaline conditions, but its secondary structure can withstand high temperatures up to 100°C and is resistant to snake venom diesterase at low Na + concentrations. Poly (G) forms stable 1:1 complexes with polycytidylic acid or poly 5-bromocytidylic acid, but does not bind to polyinosinic acid or polyadenylic acid. Poly (G) can be applied to studies on the interactions between drugs and G-rich DNA fragments in electrochemical biosensors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
