25191-14-4
Chemical Structure
Poly(G)
Synonym(s): Polyguanylic acid
- CAS No.: 25191-14-4
- Formula:(C10H14N5O8P)x
- Molecular Weight:N/A
SMILES: O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O3)=C2N=C(N)N1.[n]
Biological Activity: Poly (G) (Polyguanylic acid) is a high-molecular-weight synthetic ribopolynucleotide. In the presence of Na+ or K+ ions, Poly (G) undergoes time-dependent structural modification, gradually self-assembling from a single strand into large G-quadruplex aggregates. Poly (G) undergoes cooperative secondary structure dissociation under alkaline conditions, but its secondary structure can withstand high temperatures up to 100°C and is resistant to snake venom diesterase at low Na+ concentrations. Poly (G) forms stable 1:1 complexes with polycytidylic acid or poly 5-bromocytidylic acid, but does not bind to polyinosinic acid or polyadenylic acid. Poly (G) can be applied to studies on the interactions between drugs and G-rich DNA fragments in electrochemical biosensors[1][2].
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Poly(G) | Poly (G) (Polyguanylic acid) is a high-molecular-weight synthetic ribopolynucleotide. In the presence of Na+ or K+ ions, Poly (G) undergoes time-dependent structural modification, gradually self-assembling from a single strand into large G-quadruplex aggregates. Poly (G) undergoes cooperative secondary structure dissociation under alkaline conditions, but its secondary structure can withstand high temperatures up to 100°C and is resistant to snake venom diesterase at low Na+ concentrations. Poly (G) forms stable 1:1 complexes with polycytidylic acid or poly 5-bromocytidylic acid, but does not bind to polyinosinic acid or polyadenylic acid. Poly (G) can be applied to studies on the interactions between drugs and G-rich DNA fragments in electrochemical biosensors. | |||||||||||||||||||||
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References
- [1]. Chiorcea-Paquim A M, et al. Time-dependent polyguanylic acid structural modifications[J]. Electrochemistry communications, 2014, 45: 71-74.
- [2]. Pochon F, Michelson A M. Polynucleotides. VI. Interaction between polyguanylic acid and polycytidylic acid[J]. Proceedings of the National Academy of Sciences, 1965, 53(6): 1425-1430.
