1 Result for "

Karacoline

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Karacoline" in MCE Product Catalog:

Karacoline
Karacoline
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Cat. No.: HY-N6812
CAS No.: 39089-30-0
Category:  

Terpenoids Ranunculaceae Diterpenoids  Aconitum carmichaeli Debx. Plants Disease Research Fields Endocrinology

Target:  

NF-κB PPAR ERK JNK p38 MAPK Reactive Oxygen Species (ROS) Apoptosis MMP Collagen Interleukin Related Bcl-2 Family Caspase TNF Receptor

Karacoline is an orally active PPARγ activator and ERK/JNK MAPK inhibitor. Karacoline restricts ROS production, maintains mitochondrial membrane potential, and inhibits pulmonary cell apoptosis. Karacoline inhibits NF-κB pathway activation, reduces acetylation levels of p65 and the expression of MMP14 and MMP9, enhances the expression of type II collagen (collagen II) and aggrecan (aggrecan), and suppresses extracellular matrix degradation. In a mouse model of sepsis-induced acute lung injury, Karacoline alleviates lung injury, inhibits the release of IL-1β, IL-6 and TNF-α, increases the Bcl-2/BAX ratio, and reduces caspase 3 expression. Karacoline can be used in research related to acute lung injury and intervertebral disc degeneration .
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