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LLC0424N

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-185557
    LLC0424N

    		Histone Methyltransferase Cancer
    LLC0424N is a negative control compound designed by methylating the thalidomide moiety of LLC0424 (HY-161574). LLC0424N shows does not induce NSD2 degradation and inhibit growth of acute lymphoblastic leukemia cells with NSD2 mutation. LLC0424N can be used for the research of acute lymphoblastic leukemia .
    LLC0424N
  • HY-W1005059
    N-Methylthalidomide

    		Ligands for E3 Ligase Cancer
    N-Methylthalidomide is a cereblon ligand derivative that acts as an E3 ubiquitin ligase ligand for the synthesis of PROTAC LLC0424N (HY-185557). LLC0424N serves as a negative control for NSD2 PROTAC degrader LLC0424 (HY-161574), with weak ability to induce NSD2 degradation and low growth inhibitory effect on cancer cells carrying NSD2 mutations .
    N-Methylthalidomide
  • HY-185558
    N-Methylthalidomide-Pip-NHBoc

    		E3 Ligase Ligand-Linker Conjugates Others
    N-Methylthalidomide-Pip-NHBoc is an E3 ligase ligand-linker conjugate that incorporates the CRBN ligand and a linker. N-Methylthalidomide-Pip-NHBoc can be used to synthesize LLC0424N (HY-185557) .
    N-Methylthalidomide-Pip-NHBoc

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