42472-93-5
42472-93-5
Chemical Structure
N-Methylthalidomide
- CAS No.: 42472-93-5
- Formula:C14H12N2O4
- Molecular Weight:272.26
InChIKey: IYYPLFUVXTVBLD-UHFFFAOYSA-N
SMILES: O=C1N(C(CC2)C(N(C)C2=O)=O)C(C3=C1C=CC=C3)=O
Biological Activity: N-Methylthalidomide is a cereblon ligand derivative that acts as an E3 ubiquitin ligase ligand for the synthesis of PROTAC LLC0424N (HY-185557). LLC0424N serves as a negative control for NSD2 PROTAC degrader LLC0424 (HY-161574), with weak ability to induce NSD2 degradation and low growth inhibitory effect on cancer cells carrying NSD2 mutations[1].
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N-Methylthalidomide | 98.0% | N-Methylthalidomide is a cereblon ligand derivative that acts as an E3 ubiquitin ligase ligand for the synthesis of PROTAC LLC0424N (HY-185557). LLC0424N serves as a negative control for NSD2 PROTAC degrader LLC0424 (HY-161574), with weak ability to induce NSD2 degradation and low growth inhibitory effect on cancer cells carrying NSD2 mutations. | ||||||||||||||||||||
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References
Keywords
