3 Results for "

Lenalidomide-Br

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Lenalidomide-Br" in MCE Product Catalog:

Cat. No.: HY-43722
CAS No.: 2093387-36-9
Target:  

Ligands for E3 Ligase

Research Areas:  

Cancer

Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602) .
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1
1 Cited Publications
Cat. No.: HY-P10899
Target:  

PROTACs TGF-beta/Smad

Research Areas:  

Endocrinology

ETTAC-2 is a LRG1 PROTAC degrader, degrading LRG1 via the ubiquitin-proteasome pathway with a DC50 value of 8.38 μM. ETTAC-2 penetrates damaged renal cells to reduce the extracellular secretion of LRG1. ETTAC-2 effectively inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated extracellular matrix proteins. ETTAC-2 degrades LRG1 within fibrotic kidneys and the efficacy in inhibiting the TGF-β-Smad3 pathway both in vitro and vivo. ETTAC-2 can be used for renal fibrosis research .
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Cat. No.: HY-W591717
CAS No.: 2138440-39-6
Research Areas:  

Others

EM-12-alkyne-C3-NH2 is a conjugate of the E3 ligase ligand Lenalidomide-Br (HY-43722) and linker. EM-12-alkyne-C3-NH2 can be conjugated with MI-1061 (HY-125858) to synthesize the PROTAC MD-224 (HY-114312) .
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