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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
Lipid binding pocket
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "Lipid binding pocket" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-W195984
CAS No.: 1016340-64-9
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Z57346765 is an inhibitor that targets the ADP-binding pocket of PGK1, with a Kd of 20.9 μM for human PGK1, and exhibits anticancer activity. Z57346765 reduces the activity of the metabolic enzyme PGK1 during glycolysis, regulates lipid peroxidation and cancer cell proliferation, and promotes lipid peroxidation in cervical cancer cells. Z57346765 inhibits the proliferation of cervical cancer and clear cell renal cell carcinoma cells in xenograft mouse models, and induces the expression of genes associated with cell metabolism, DNA replication and cell cycle. Z57346765 is used in research related to cervical cancer, clear cell renal cell carcinoma and breast cancer .
Cat. No.: HY-163114
CAS No.: 2170888-39-6
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2-Stearoxyphenethyl phosphocholin (compound 1a) is a p38 MAPK inhibitor with anticancer activity. 2-Stearoxyphenethyl phosphocholin may bind to the p38 MAPK lipid-binding pocket and has broad-spectrum anti-tumor and lipid-modulating activities .
Cat. No.: HY-163115
CAS No.: 2170888-41-0
2-Oleoxyphenethyl phosphocholin (compound 1b) is a p38 MAPK inhibitor with anticancer activity. 2-Oleoxyphenethyl phosphocholin may bind to the p38 MAPK lipid-binding pocket and has broad-spectrum anti-tumor and lipid-modulating activities .
Cat. No.: HY-182020
LpxH-IN-3 is a Klebsiella pneumoniae LpxH inhibitor with an IC50 of 0.17 μM. LpxH-IN-3 binds to the L-shaped hydrophobic binding pocket of Klebsiella pneumoniae LpxH, forms hydrogen bonds and other interactions with key residues, disrupts lipid A biosynthesis, and induces bacterial death. LpxH-IN-3 exhibits moderate antibacterial activity against Klebsiella pneumoniae and Escherichia coli. LpxH-IN-3 can be used for the research of klebsiella pneumoniae infection .
Cat. No.: HY-184489
CAS No.: 328265-32-3
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PGP/FSP1-IN-1 is a dual PGP and FSP1 inhibitor and ferroptosis inducer that inhibits the oxidoreductase activity of FSP1. PGP/FSP1-IN-1 competes with NAD (P) H for binding to the pocket of FSP1 and induces FSP1 self-assembly, thereby directly blocking the catalytic function of the relevant enzyme. PGP/FSP1-IN-1 promotes lipid peroxidation and significantly enhances cellular sensitivity to ferroptosis when GPX4 activity is impaired or glutathione synthesis is inhibited. PGP/FSP1-IN-1 can be used in cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
