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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
MDH1
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "MDH1" in MCE Product Catalog:
1
1 Cited Publications
Áreas de investigación:
MDH1-IN-2 (Compound 7c) is a selective MDH1 inhibitor, with IC50 values of 2.27 and 27.47 μM for MDH1 and MDH2, respectively. MDH1-IN-2 can reduce the generation of ROS by inhibiting the conversion of 2-Ketoglutaric acid (HY-W013636) to α-Hydroxyglutaric acid (HY-113038B) mediated by MDH1, thereby suppressing 2-Ketoglutaric acid (HY-W013636)-induced ferroptosis [1] .
1
1 Cited Publications
Target:
Áreas de investigación:
MDH1-IN-1 is a selective MDH1 inhibitor with an IC50 of 6.79 μM against human targets. MDH1-IN-1 exhibits in vivo anti-tumor efficacy. MDH1-IN-1 can be used for the research of colorectal cancer [1].
Referencia número: HY-W613220
No. CAS: 2143473-95-2
Áreas de investigación:
MDH1/2-IN-1 is a MDH1/2 inhibitor (IC50: 1.07 μM and 1.06 μM respectively). MDH1/2-IN-1 inhibits mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 demonstrates significant anti-tumor potential. MDH1/2-IN-1 provides a new direction for the development of drugs targeting cancer metabolism [1].
Referencia número: HY-RS08260
Target:
Áreas de investigación:
MDH1 Human Pre-designed siRNA Set A contains three designed siRNAs for MDH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS16793
Target:
Áreas de investigación:
Mdh1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mdh1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS23233
Target:
Áreas de investigación:
Mdh1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mdh1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS17185
Target:
Áreas de investigación:
Me1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Me1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
