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MELAS

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128895
    KL1333
    1 Publications Verification

    		 Quinone Reductase Mitochondrial Metabolism Metabolic Disease
    KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .
    KL1333
  • HY-172558
    MEL-A

    		Biochemical Assay Reagents Others
    MEL-A is a glycolipid biosurfactant. MEL-A can be produced from vegetable oils by Pseudozyma yeasts. MEL-A can improve the low-temperature fluidity of biodiesel and hydrocarbon fuels. MEL-A is composed of a mixture of MEL-A isoforms with variable lengths of the fatty acid chain. MEL-A can significantly increases gene transfection by cationic liposomes via membrane fusion .
    MEL-A
  • HY-128895A
    KL1333 hydrochloride

    		Mitochondrial Metabolism Quinone Reductase Metabolic Disease
    KL1333 hydrochloride is an orally active NAD + modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD + levels through NADH oxidation. Elevated NAD + levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures .
    KL1333 hydrochloride
  • HY-149193
    5-Taurinomethyluridine

    		Endogenous Metabolite Metabolic Disease
    5-Taurinomethyluridine is a taurine-containing modified uridine and translation regulator that exists in Trp and Leu (UUR) tRNAs of mammalian mitochondria. 5-Taurinomethyluridine is located at the first position of the anticodon of these mitochondrial tRNAs. 5-Taurinomethyluridine is synthesized from taurine and one-carbon metabolites by GTPBP3/MTO1, and its deficiency directly causes abnormal mitochondrial translation and various human mitochondrial diseases .
    5-Taurinomethyluridine

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