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Cat. No.: HY-149193

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5-Taurinomethyluridine

5-Taurinomethyluridine is a taurine-containing modified uridine and translation regulator that exists in Trp and Leu (UUR) tRNAs of mammalian mitochondria. 5-Taurinomethyluridine is located at the first position of the anticodon of these mitochondrial tRNAs. 5-Taurinomethyluridine is synthesized from taurine and one-carbon metabolites by GTPBP3/MTO1, and its deficiency directly causes abnormal mitochondrial translation and various human mitochondrial diseases.

For research use only. We do not sell to patients.

CAS No.: 497258-53-4
Formula: C₁₂H₁₉N₃O₉S
Molecular Weight:381.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

5-Taurinomethyluridine Chemical Structure

CAS No.: 497258-53-4

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Description

All Endogenous Metabolite Isoforms :

In Vitro

5-taurinomethyluridine is a modified nucleoside present in the anticodon region of human and ascidian mt tRNAs for Trp and Leu(UUR), with a molecular mass of 381 Da and a sulfonic acid-containing taurinomethyl side chain at position 5 of the uracil base^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 497258-53-4
Molecular Weight 381.36
Formula C₁₂H₁₉N₃O₉S
SMILES

O=S(CCNCC(C(N1)=O)=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1=O)(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Suzuki T, et al. Novel taurine-containing uridine derivatives and mitochondrial human diseases. Nucleic Acids Res Suppl. 2001;(1):257-258. [Content Brief]

[2]. Asano K, et al. Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease. Nucleic Acids Res. 2018;46(4):1565-1583. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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5-Taurinomethyluridine

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All Endogenous Metabolite Isoforms

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5-Taurinomethyluridine Related Classifications

HY-149193 Related Classifications