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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
MR-1
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "MR-1" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: 7-Sulfocholic acid
Research Areas:
Cholic acid 7-sulfate (7-Sulfocholic acid) is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation [1] .
1
Cat. No.: HY-150356MR1
Category:
Target:
Cat. No.: HY-150354MR1
Synonyms: #N/A
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Mixture of 9 Antioxidants in Acetonitrile (Standard) is mainly used for the determination of antioxidants in food and is suitable for the use of standard products in GB 5009.32
Cat. No.: HY-150353MR1
Synonyms: #N/A
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17-Estradiol, Estriol, Ethinylestradiol and Estrone in Methanol (Standard) is mainly used for the detection of hormone components in foods and cosmetics, and is suitable for use as standard products in GB 31658.7.
Cat. No.: HY-P990134
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Synonyms: Ac-6-FP
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Acetyl-6-formylpterin (Ac-6-FP) is a hapten that covalently binds to MR1 through residue Lys43 of the protein, resulting in protein upregulation. Acetyl-6-formylpterin (Ac-6-FP) can be used in the study of inflammation [1].
Cat. No.: HY-32955
CAS No.: 444120-91-6
Cat. No.: HY-P990269
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Cat. No.: HY-W168754
CAS No.: 16296-42-7
DB28 is a novel MR1 ligand. DB28 decreases cell surface expression of MR1 and competitively inhibits activation of MAIT cells by agonist ligands [1].
Synonyms: PLIII
Target:
Research Areas:
Photolumazine III (PLIII) is a microbial metabolite and derivative of Riboflavin (HY-B0456). Photolumazine III binds MR1 with high specificity. Photolumazine III supports efficient TCR binding. Photolumazine III acts as an antigen to activate cells. Responses to Photolumazine III trigger immune reactions [1].
Cat. No.: HY-P990270
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Cat. No.: HY-RS08637
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MR1 Human Pre-designed siRNA Set A contains three designed siRNAs for MR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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5-Formylsalicylic acid (5-F-SA), a hapten, strongly upregulates MR1 expression (MR1 ligand) [1].
Cat. No.: HY-126855S
CAS No.: 1332881-66-9
Synonyms: 7-Sulfocholic acid-d4
Cat. No.: HY-182894
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MR1-114 is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 0.037 μM. As a broad-spectrum inhibitor, MR1-114 maintains submicromolar activity against SARS-CoV-2 Delta, Omicron B.1.1.529 and Omicron BA.5 variants, with EC50 values of 0.18 μM, 0.39 μM and 0.20 μM, respectively. MR1-114 can be used for the research of coronavirus disease 2019 (SARS-CoV-2 infection) [1].
Cat. No.: HY-P705394
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MR1 & B2M; Major histocompatibility complex class I-related protein 1; MR1;
MHC class I-related protein 1;
Class I histocompatibility antigen-like protein; MR1
Cat. No.: HY-P11249
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Cat. No.: HY-RS10777
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PNKD Human Pre-designed siRNA Set A contains three designed siRNAs for PNKD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
