29769-49-1
Chemical Structure
Acetyl-6-formylpterin
Synonym(s): Ac-6-FP
- CAS No.: 29769-49-1
- Formula:C9H7N5O3
- Molecular Weight:233.18
IUPAC Name: N-(6-formyl-4-oxo-4,8-dihydropteridin-2-yl)acetamide
InChIKey: DDBCPKAHJKOGKK-UHFFFAOYSA-N
SMILES: O=CC1=CNC2=NC(NC(C)=O)=NC(C2=N1)=O
Biological Activity: Acetyl-6-formylpterin (Ac-6-FP) is a hapten that stabilizes MR1 on antigen-presenting cells, forming an MR1:A6FP complex that fails to activate MAIT cell TCR, thereby acting as a competitive inhibitor of MAIT cell activation. Acetyl-6-formylpterin exacerbates house dust mite-induced airway hyperresponsiveness and elevates circulating IgE levels. Acetyl-6-formylpterin reduces systemic MAIT cell activity and decreases the frequency of IL-17A+ and IFNγ+ MAIT cells in the spleen. Acetyl-6-formylpterin is useful for the study of allergic asthma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Acetyl-6-formylpterin | 97.06% | Acetyl-6-formylpterin (Ac-6-FP) is a hapten that stabilizes MR1 on antigen-presenting cells, forming an MR1:A6FP complex that fails to activate MAIT cell TCR, thereby acting as a competitive inhibitor of MAIT cell activation. Acetyl-6-formylpterin exacerbates house dust mite-induced airway hyperresponsiveness and elevates circulating IgE levels. Acetyl-6-formylpterin reduces systemic MAIT cell activity and decreases the frequency of IL-17A+ and IFNγ+ MAIT cells in the spleen. Acetyl-6-formylpterin is useful for the study of allergic asthma. | ||||||||||||||||||||
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