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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
Maytansinoid DM1
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "Maytansinoid DM1" in MCE Product Catalog:
28
Target:
Research Areas:
Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC) .
Cat. No.: HY-132262
CAS No.: 1008106-64-6
Synonyms: IMGN-901; BB-1090
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Research Areas:
Lorvotuzumab mertansine is an ADC consisting of a humanized N901 monoclonal antibody against CD56 bound to maytansinoid DM1 via a stable disulfide linker. Lorvotuzumab mertansine has antitumor activity .
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DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is the microtubule inhibitor and can be used as the ADC cytotoxin .
Cat. No.: HY-136261
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Research Areas:
DM1-(PEG)4-DBCO is a drug-linker conjugate composed of the tubulin inhibitor DM1 (HY-19792) and the linker DBCO-PEG4-Ahx. DM1 is a tubulin inhibitor and an antibody-conjugated maytansinoid; it was developed to overcome the systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1-PEG4-DBCO is a click chemistry reagent.
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Research Areas:
DBCO-PEG4-Ahx-DM1 is a agent-linker conjugate composed of a potent microtubulin inhibitor DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DBCO-PEG4-Ahx-DM1 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Cat. No.: HY-19792S2
Synonyms: DM1-d3; Maytansinoid DM1-d3
Cat. No.: HY-19792S
Synonyms: DM1-13C,d3; Maytansinoid DM1-13C,d3
Cat. No.: HY-P81055
Synonyms: Mertansine, Maytansinoid DM1, DM 1, 139504-50-0
Cat. No.: HY-100128R
CAS No.: 138148-68-2
Research Areas:
DM1-SMe (Standard) is the analytical standard of DM1-SMe (HY-100128). This product is intended for research and analytical applications. DM1-SMe is an unconjugated form of the Maytansinoid in IMGN901. DM1-SMe is the microtubule inhibitor and can be used as the ADC cytotoxin .
Cat. No.: HY-185483
Research Areas:
AMG-172 is an antibody-drug conjugate (ADC) composed of a fully human IgG1 monoclonal anti-CD27L antibody conjugated to DM1 (HY-19792) via the non-cleavable linker MCC. AMG-172 releases the intracellular active component Lysine-MCC-DM through catabolism. Lysine-MCC-DM inhibits the assembly and disassembly dynamics of Microtubule and induces cell arrest at metaphase. AMG-172 can be used for research on relapsed/refractory clear cell renal cell carcinoma .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
