2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. DM1-PEG4-DBCO

DM1-PEG4-DBCO 

Cat. No.: HY-136261
Handling Instructions

DM1-(PEG)4-DBCO is a agent-linker conjugate composed of a potent microtubulin?inhibitor?DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC). Mertansine (DM1) is a?microtubulin?inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.

For research use only. We do not sell to patients.

DM1-PEG4-DBCO Chemical Structure

DM1-PEG4-DBCO Chemical Structure

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Description

DM1-(PEG)4-DBCO is a agent-linker conjugate composed of a potent microtubulin?inhibitor?DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC). Mertansine (DM1) is a?microtubulin?inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.

IC50 & Target

Maytansinoids

 

Molecular Weight

1198.79

Appearance

Solid

Formula

C63H80ClN5O16
SMILES

COC1=CC(C/C(C)=C/C=C/[[email protected]@H](OC)[[email protected]]2(O)NC(O[[email protected]@]([[email protected]@H](C)[[email protected]@](O3)([H])[[email protected]]3(C)[[email protected]@H](OC([[email protected]](C)N(C)C(CCCOCCOCCOCCOCCNC(CCC(N4CC(C=CC=C5)=C5C#CC6=C4C=CC=C6)=O)=O)=O)=O)CC7=O)([H])C2)=O)=CC(N7C)=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DM1-PEG4-DBCODrug-Linker Conjugates for ADCADCcancerconjugatemaytansinoidInhibitorinhibitorinhibit

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