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Cat. No.: HY-136260

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DBCO-PEG4-Ahx-DM1

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DBCO-PEG4-Ahx-DM1 is a agent-linker conjugate composed of a potent microtubulin inhibitor DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DBCO-PEG4-Ahx-DM1 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Purity: 94.44%
CAS No.: 2479378-44-2
Formula: C₆₈H₈₉ClN₆O₁₇
Molecular Weight:1297.92

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

DBCO-PEG4-Ahx-DM1 Chemical Structure

CAS No.: 2479378-44-2

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Bioz

Biological Activity

Description

IC₅₀ & Target

Maytansinoids

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

Antibody-drug conjugates (ADCs) carry a highly potent small-molecule toxin covalently connected on the antibody via a proper linker. For therapeutic ADCs in cancer treatment, the antibody targets specific antigen of tumor cell surface with high binding affinity, thereafter the intact ADC was internalized into the tumor cells with the antigen and digested in the lysosome to release the antitumor toxin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2479378-44-2
Appearance Solid
Molecular Weight 1297.92
Formula C₆₈H₈₉ClN₆O₁₇
Color White to off-white
SMILES

COC1=CC(C/C(C)=C/C=C/[C@@H](OC)[C@]2(O)NC(O[C@@]([C@@H](C)[C@@](O3)([H])[C@]3(C)[C@@H](OC([C@H](C)N(C)C(CCCCCNC(CCOCCOCCOCCOCCNC(CCC(N4CC(C=CC=C5)=C5C#CC6=C4C=CC=C6)=O)=O)=O)=O)=O)CC7=O)([H])C2)=O)=CC(N7C)=C1Cl
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Room temperature in continental US; may vary elsewhere.