1 Result for "

Meridianin C

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Meridianin C" in MCE Product Catalog:

Meridianin C
Meridianin C
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Cat. No.: HY-W107409
CAS No.: 213473-00-8
Category:  

Alkaloids Other Alkaloids Marine natural products

Target:  

Others

Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation .
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