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N 0840

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0840
    Bruceantin
    2 Publications Verification

    (-)-Bruceantin; NCI165563; NSC165563

    		 c-Myc Caspase Mitochondrial Metabolism Apoptosis Parasite Infection Cancer
    Bruceantin ((-)-Bruceantin) is a quassinoid found in B. javanica. Bruceantin activates caspase signaling pathway, causes the mitochondrial dysfunction, inhibits cell proliferation, induces cell differentiation and apoptosis. Bruceantin exhibits anti-leukemia and antiprotozoal activities .
    Bruceantin
  • HY-182714
    N 0840

    N6-Cyclopentyl-9-methyladenine

    		 Adenosine Receptor Cardiovascular Disease Neurological Disease
    N 0840 is a neutral antagonist of adenosine A1 receptor (A1AR), with a Ki value of 279 nM in rats and 1185 nM in humans. N 0840 modulates adenosine A1 receptor to increase forskolin-induced cyclic 3′,5′-adenosine monophosphate production, with a GTP shift value close to 1. N 0840 can be used in studies of neuroprotection, cardiovascular/renal function[1].
    N 0840

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