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Results for "

NCoR1

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-176851
    GSK1362

    		REV-ERB Inflammation/Immunology
    GSK1362 is a selective inverse agonist of REV-ERB. GSK1362disrupts the interaction of REV-ERBα with repressive co-modulators (NCoR1, SMRT2, RIP140). GSK1362 exerts an inverse agonist effect by increasing the transcription of BMAL1 to relieve BMAL1 repression by endogenous REV-ERB ligands. GSK1362 suppresses LPS (HY-D1056)-induced inflammatory cytokine expression, inhibits IL-1β-induced Cxcl5 transcription in cells. GSK1362 can be used for the study of inflammatory diseases [1].
    GSK1362
  • HY-RS09096
    NCOR1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NCOR1 Human Pre-designed siRNA Set A contains three designed siRNAs for NCOR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NCOR1 Human Pre-designed siRNA Set A
    NCOR1 Human Pre-designed siRNA Set A
  • HY-121900
    LT175

    		PPAR Metabolic Disease Endocrinology
    LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties [1].
    LT175
  • HY-RS26961
    Ncor1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ncor1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ncor1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ncor1 Rat Pre-designed siRNA Set A
    Ncor1 Rat Pre-designed siRNA Set A
  • HY-RS20452
    Ncor1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ncor1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ncor1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ncor1 Mouse Pre-designed siRNA Set A
    Ncor1 Mouse Pre-designed siRNA Set A
  • HY-177756
    BCL6-IN-11

    		BCL6 Cancer
    BCL6-IN-11 (Compound 8) is an efficient inhibitor that induces partial degradation of BCL6 with its IC50 value for inhibiting the interaction between BCL6 and its co-inhibitory proteins (such as NCOR1) of 6 nM. BCL6-IN-11 can induce approximately 52% degradation of BCL6 after being treated with 5 μM concentration for 90 minutes, and thus is also classified as a partial degrader. BCL6-IN-11 can be used for the study of lymphoma [1].
    BCL6-IN-11

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