NCOR1 Antibody (YA3556)(PBS only)

Cat. No.: HY-P83859A: Data Sheet User Guide for Antibodies
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NCOR1 Antibody (YA3556) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NCOR1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

NCOR1 Antibody (YA3556) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NCOR1.

Host

Mouse

Molecular Weight

Predicted band size: 270 kDa;

Observed band size: 270 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

O75376

Gene ID

9611 [NCBI]

Immunogen

Purified recombinant fragment of NCOR1 (aa1-192) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity)

Subcellular Localization：Nucleus

Isoforms & Post-Translational Modification：O75376 has 3 isomers: O75376-1: 270210 Da (predicted); O75376-2: 258602 Da (predicted); O75376-3: 103919 Da (predicted).
Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation

Subunit：Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation.

Synonyms

N-CoR; TRAC1; hN-CoR

Documentation

User Guide for Antibodies (1077 KB)