2230406-60-5
Chemical Structure
BCL6-IN-11
- CAS No.: 2230406-60-5
- Formula:C22H24Cl2N6O3
- Molecular Weight:491.37
InChIKey: XJEHQOYXLMUBLC-UHFFFAOYSA-N
SMILES: CNC(COC1=CC2=CC(NC3=NC(N4CCC(CC4)Cl)=NC=C3Cl)=CC=C2N(C1=O)C)=O
Biological Activity: BCL6-IN-11 (Compound 8) is an efficient inhibitor that induces partial degradation of BCL6 with its IC50 value for inhibiting the interaction between BCL6 and its co-inhibitory proteins (such as NCOR1) of 6 nM. BCL6-IN-11 can induce approximately 52% degradation of BCL6 after being treated with 5 μM concentration for 90 minutes, and thus is also classified as a partial degrader. BCL6-IN-11 can be used for the study of lymphoma[1].
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BCL6-IN-11 | BCL6-IN-11 (Compound 8) is an efficient inhibitor that induces partial degradation of BCL6 with its IC50 value for inhibiting the interaction between BCL6 and its co-inhibitory proteins (such as NCOR1) of 6 nM. BCL6-IN-11 can induce approximately 52% degradation of BCL6 after being treated with 5 μM concentration for 90 minutes, and thus is also classified as a partial degrader. BCL6-IN-11 can be used for the study of lymphoma. | |||||||||||||||||||||
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Keywords
