862901-87-9
Chemical Structure
LT175
- CAS No.: 862901-87-9
- Formula:C21H18O3
- Molecular Weight:318.37
IUPAC Name: (S)-2-([1,1'-biphenyl]-4-yloxy)-3-phenylpropanoic acid
InChIKey: TZTPJJNNACUQQR-FQEVSTJZSA-N
SMILES: O=C([C@@H](OC1=CC=C(C2=CC=CC=C2)C=C1)CC3=CC=CC=C3)O
Biological Activity: LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LT175 | 99.46% | LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties. | ||||||||||||||||||||
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Keywords
