PPARα/γ agonist 2
PPARα/γ agonist 2 is an orally active PPARα full agonist and PPARγ partial agonist. PPARα/γ agonist 2 activates PPARα and PPARγ with EC50 values of 0.95 μM and 0.91 μM respectively. PPARα/γ agonist 2 is also a PTP1B inhibitor. PPARα/γ agonist 2 is an anti-diabetic agent.
For research use only. We do not sell to patients.
- CAS No.: 2213365-56-9
- Formula: C25H20O3
- Molecular Weight:368.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
PPARα 0.95 μM (EC50) |
PPARγ 0.91 μM (EC50) |
In Vitro
PPARα/γ agonist 2 (Compound 10) effectively inhibits PTP1B with an IC50 of 13.2 μM (kinetic assay)[1].
PPARα/γ agonist 2 (25 μM, 30 min) enhances the uptake of glucose in an insulin-independent mechanism in C2C12 cells, and is more efficient than UK5099 (HY-15475)[1].
PPARα/γ agonist 2 (25 μM, 30 min) decreases mitochondrial membrane potential in C2C12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:STZ-induced diabetic mice[1]
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Dosage:25 and 50 mg/kg
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Administration:p.o.
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Result:Reduced the levels of TC, HDL, LDL-C, VLDL-C, and TG.
Brought diabetes-induced hyperlipidemia back to normal.
Chemical Information
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CAS No. 2213365-56-9
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Molecular Weight 368.42
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Formula C25H20O3
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SMILES
O=C(C(CC1=CC=CC2=C1C=CC=C2)OC3=CC=C(C4=CC=CC=C4)C=C3)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PPARα/γ agonist 2 Related Classifications
HY-148922 Related Classifications
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