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Art. -Nr.: HY-148922

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PPARα/γ agonist 2

PPARα/γ agonist 2 is an orally active PPARα full agonist and PPARγ partial agonist. PPARα/γ agonist 2 activates PPARα and PPARγ with EC₅₀ values of 0.95 μM and 0.91 μM respectively. PPARα/γ agonist 2 is also a PTP1B inhibitor. PPARα/γ agonist 2 is an anti-diabetic agent.

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CAS. Nr.: 2213365-56-9
Formel: C₂₅H₂₀O₃
Molecular Weight:368.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

PPARα/γ agonist 2 Chemical Structure

CAS. Nr.: 2213365-56-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

PPARα

0.95 μM (EC₅₀)

PPARγ

0.91 μM (EC₅₀)

Alle PPAR Isoform-spezifische Produkte anzeigen :

In Vitro

PPARα/γ agonist 2 (Compound 10) effectively inhibits PTP1B with an IC₅₀ of 13.2 μM (kinetic assay)^[1].
PPARα/γ agonist 2 (25 μM, 30 min) enhances the uptake of glucose in an insulin-independent mechanism in C2C12 cells, and is more efficient than UK5099 (HY-15475)^[1].
PPARα/γ agonist 2 (25 μM, 30 min) decreases mitochondrial membrane potential in C2C12 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PPARα/γ agonist 2 (Compound 10) (25 and 50 mg/kg, p.o.) decreases blood glucose level and lipid content in STZ-induced diabetic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

STZ-induced diabetic mice^[1]
Dosage:

25 and 50 mg/kg
Administration:

p.o.
Result:

Reduced the levels of TC, HDL, LDL-C, VLDL-C, and TG.
Brought diabetes-induced hyperlipidemia back to normal.

Chemical Information

CAS. Nr. 2213365-56-9
Molecular Weight 368.42
Formel C₂₅H₂₀O₃
SMILES

O=C(C(CC1=CC=CC2=C1C=CC=C2)OC3=CC=C(C4=CC=CC=C4)C=C3)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Laghezza A, et al. A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition. J Med Chem. 2023 Feb 15. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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PPARα/γ agonist 2

Alle PPAR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PPARα/γ agonist 2 Related Classifications

HY-148922 Related Classifications