PPARα/γ agonist 2
PPARα/γ agonist 2 is an orally active PPARα full agonist and PPARγ partial agonist. PPARα/γ agonist 2 activates PPARα and PPARγ with EC50 values of 0.95 μM and 0.91 μM respectively. PPARα/γ agonist 2 is also a PTP1B inhibitor. PPARα/γ agonist 2 is an anti-diabetic agent.
For research use only. We do not sell to patients.
- CAS No.: 2213365-56-9
- Formula: C25H20O3
- Molecular Weight:368.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PPARα 0.95 μM (EC50) |
PPARγ 0.91 μM (EC50) |
PPARα/γ agonist 2 (Compound 10) effectively inhibits PTP1B with an IC50 of 13.2 μM (kinetic assay)[1].
PPARα/γ agonist 2 (25 μM, 30 min) enhances the uptake of glucose in an insulin-independent mechanism in C2C12 cells, and is more efficient than UK5099 (HY-15475)[1].
PPARα/γ agonist 2 (25 μM, 30 min) decreases mitochondrial membrane potential in C2C12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:STZ-induced diabetic mice[1]
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Dosage:25 and 50 mg/kg
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Administration:p.o.
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Result:Reduced the levels of TC, HDL, LDL-C, VLDL-C, and TG.
Brought diabetes-induced hyperlipidemia back to normal.
Chemical Information
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CAS No. 2213365-56-9
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Molecular Weight 368.42
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Formula C25H20O3
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SMILES
O=C(C(CC1=CC=CC2=C1C=CC=C2)OC3=CC=C(C4=CC=CC=C4)C=C3)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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