1. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  2. PPAR
  3. PPARα/γ agonist 2

PPARα/γ agonist 2 is an orally active PPARα full agonist and PPARγ partial agonist. PPARα/γ agonist 2 activates PPARα and PPARγ with EC50 values of 0.95 μM and 0.91 μM respectively. PPARα/γ agonist 2 is also a PTP1B inhibitor. PPARα/γ agonist 2 is an anti-diabetic agent.

For research use only. We do not sell to patients.

PPARα/γ agonist 2 Chemical Structure

PPARα/γ agonist 2 Chemical Structure

CAS No. : 2213365-56-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products

View All PPAR Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PPARα/γ agonist 2 is an orally active PPARα full agonist and PPARγ partial agonist. PPARα/γ agonist 2 activates PPARα and PPARγ with EC50 values of 0.95 μM and 0.91 μM respectively. PPARα/γ agonist 2 is also a PTP1B inhibitor. PPARα/γ agonist 2 is an anti-diabetic agent[1].

IC50 & Target[1]

PPARα

0.95 μM (EC50)

PPARγ

0.91 μM (EC50)

In Vitro

PPARα/γ agonist 2 (Compound 10) effectively inhibits PTP1B with an IC50 of 13.2 μM (kinetic assay)[1].
PPARα/γ agonist 2 (25 μM, 30 min) enhances the uptake of glucose in an insulin-independent mechanism in C2C12 cells, and is more efficient than UK5099 (HY-15475)[1].
PPARα/γ agonist 2 (25 μM, 30 min) decreases mitochondrial membrane potential in C2C12 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PPARα/γ agonist 2 (Compound 10) (25 and 50 mg/kg, p.o.) decreases blood glucose level and lipid content in STZ-induced diabetic mice[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: STZ-induced diabetic mice[1]
Dosage: 25 and 50 mg/kg
Administration: p.o.
Result: Reduced the levels of TC, HDL, LDL-C, VLDL-C, and TG.
Brought diabetes-induced hyperlipidemia back to normal.
Molecular Weight

368.42

Formula

C25H20O3

CAS No.
SMILES

O=C(C(CC1=CC=CC2=C1C=CC=C2)OC3=CC=C(C4=CC=CC=C4)C=C3)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PPARα/γ agonist 2
Cat. No.:
HY-148922
Quantity:
MCE Japan Authorized Agent: