5 Results for "

NSC32944

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "NSC32944" in MCE Product Catalog:

2
Cephaeline
Cephaeline
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2 Cited Publications
Cat. No.: HY-N4118
CAS No.: 483-17-0
Synonyms: (-)-Cephaeline; NSC 32944 free base
Category:  

Infection Alkaloids other families Monophenols Phenols Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline ((-)-Cephaeline; NSC 32944) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline induces ferroptosis (Ferroptosis) by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline inhibits cancer cell proliferation, migration and tumor growth. Cephaeline inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
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2
Cephaeline dihydrochloride
Cephaeline dihydrochloride
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2 Cited Publications
Cat. No.: HY-N2260
CAS No.: 5853-29-2
Synonyms: (-)-Cephaeline dihydrochloride; NSC 32944
Category:  

Infection Alkaloids other families Monophenols Phenols Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Cytochrome P450

Cephaeline dihydrochloride is a selective CYP2D6 inhibtor with an IC50 of 121 μM.
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Cephaeline hydrochloride
Cephaeline hydrochloride
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Cat. No.: HY-N2076
CAS No.: 3738-70-3
Synonyms: (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride
Category:  

Infection Alkaloids other families Monophenols Phenols Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline hydrochloride ((-)-Cephaeline (hydrochloride); NSC 32944 (monohydrochloride)) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline hydrochloride induces Ferroptosis by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline hydrochloride inhibits cancer cell proliferation, migration and tumor growth. Cephaeline hydrochloride inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline hydrochloride can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
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Cephaeline (Standard)
Cephaeline (Standard)
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Cat. No.: HY-N4118R
CAS No.: 483-17-0
Synonyms: (-)-Cephaeline (Standard); NSC 32944 free base (Standard)
Category:  

Alkaloids other families Monophenols Phenols Plants Isoquinoline Alkaloids

Target:  

Reference Standards Filovirus Flavivirus Keap1-Nrf2 Ferroptosis Reactive Oxygen Species (ROS)

Cephaeline ((-)-Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes ferroptosis by inhibiting NRF2 to exert anti-lung cancer efficacy .
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Cephaeline dihydrochloride (Standard)
Cephaeline dihydrochloride (Standard)
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Cat. No.: HY-N2260R
CAS No.: 5853-29-2
Synonyms: (-)-Cephaeline dihydrochloride (Standard); NSC 32944 (Standard)
Category:  

Alkaloids other families Monophenols Phenols Plants Isoquinoline Alkaloids

Target:  

Reference Standards Cytochrome P450

Cephaeline (dihydrochloride) (Standard) is the analytical standard of Cephaeline (dihydrochloride). This product is intended for research and analytical applications. Cephaeline dihydrochloride is a selective CYP2D6 inhibtor with an IC50 of 121 μM.
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