1 Result for "

Oxoglaucine

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Oxoglaucine" in MCE Product Catalog:

Oxoglaucine
Oxoglaucine
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Cat. No.: HY-N2595
CAS No.: 5574-24-3
Synonyms: O-Methylatheroline
Category:  

Alkaloids Magnoliaceae Liriodendron tulipifera L. Quinoline Alkaloids Plants Disease Research Fields Inflammation/Immunology

Target:  

NO Synthase PGE synthase TRP Channel CaMK Calmodulin TGF-beta/Smad Collagen Interleukin Related Akt TNF Receptor Caspase Bacterial Fungal Reactive Oxygen Species (ROS) Apoptosis Autophagy

Oxoglaucine (O-Methylatheroline) is a natural product with multiple activities including autophagy activation, anti-inflammation, antibacterial activity, and immunoregulation. Oxoglaucine inhibits the TRPV5/calmodulin/CAMK-II pathway, suppresses TGFβ-induced Smad2 phosphorylation by upregulating Smad7, blocks Ca 2+ influx, activates autophagy, alleviates apoptosis and inflammation, inhibits ROS production and the expression of fibrosis markers in hepatocytes, and regulates immune cell populations and responses. Oxoglaucine protects against infections caused by Candida albicans and Klebsiella pneumoniae, and exerts effects on adjuvant-induced arthritis. Oxoglaucine can be used in studies related to arthritis, liver fibrosis, bacterial infections, and fungal infections .
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