5574-24-3
Chemical Structure
Oxoglaucine
Synonym(s): O-Methylatheroline
- CAS No.: 5574-24-3
- Formula:C20H17NO5
- Molecular Weight:351.35
IUPAC Name: 1,2,9,10-tetramethoxy-7H-dibenzo[de,g]quinolin-7-one
InChIKey: ZYKCETVKVRJFGD-UHFFFAOYSA-N
SMILES: O=C1C2=CC(OC)=C(OC)C=C2C3=C(OC)C(OC)=CC4=CC=NC1=C43
Biological Activity: Oxoglaucine (O-Methylatheroline) is a natural product with multiple activities including autophagy activation, anti-inflammation, antibacterial activity, and immunoregulation. Oxoglaucine inhibits the TRPV5/calmodulin/CAMK-II pathway, suppresses TGFβ-induced Smad2 phosphorylation by upregulating Smad7, blocks Ca2+ influx, activates autophagy, alleviates apoptosis and inflammation, inhibits ROS production and the expression of fibrosis markers in hepatocytes, and regulates immune cell populations and responses. Oxoglaucine protects against infections caused by Candida albicans and Klebsiella pneumoniae, and exerts effects on adjuvant-induced arthritis. Oxoglaucine can be used in studies related to arthritis, liver fibrosis, bacterial infections, and fungal infections[1][2][3][4][5].
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Oxoglaucine | Oxoglaucine (O-Methylatheroline) is a natural product with multiple activities including autophagy activation, anti-inflammation, antibacterial activity, and immunoregulation. Oxoglaucine inhibits the TRPV5/calmodulin/CAMK-II pathway, suppresses TGFβ-induced Smad2 phosphorylation by upregulating Smad7, blocks Ca2+ influx, activates autophagy, alleviates apoptosis and inflammation, inhibits ROS production and the expression of fibrosis markers in hepatocytes, and regulates immune cell populations and responses. Oxoglaucine protects against infections caused by Candida albicans and Klebsiella pneumoniae, and exerts effects on adjuvant-induced arthritis. Oxoglaucine can be used in studies related to arthritis, liver fibrosis, bacterial infections, and fungal infections. | |||||||||||||||||||||
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- [1]. Zhong G, et al. Oxoglaucine mediates Ca influx and activates autophagy to alleviate osteoarthritis through the TRPV5/calmodulin/CAMK-II pathway. British journal of pharmacology. 2021 Aug;178(15):2931-2947. [Content Brief]
- [2]. Azamov B, et al. Oxoglaucine Suppresses Hepatic Fibrosis by Inhibiting TGFβ-Induced Smad2 Phosphorylation and ROS Generation. Molecules (Basel, Switzerland). 2023 Jun 24;28(13):4971.
- [3]. Harrigan GG, et al. Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea. Journal of natural products. 1994 Jan;57(1):68-73. [Content Brief]
- [4]. Ivanovska N, et al. Immunopharmacological activity of aporphinoid alkaloid oxoglaucine. Pharmacological research. 1997 Apr;35(4):267-72.
- [5]. Ivanovska N, et al. Treatment with oxoglaucine can enhance host resistance to Candida albicans infection of mice with adjuvant arthritis. Diagnostic microbiology and infectious disease. 2000 Sep;38(1):17-20.
Keywords
