Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea
- J Nat Prod. 1994 Jan;57(1):68-73. doi: 10.1021/np50103a009.
- 1. Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, 24061-0212.
The oxoaporphine Alkaloids oxophoebine [1] and liriodenine [2] have been isolated from Xylopia aethiopica (Annonaceae). Both showed selective toxicity against DNA repair and recombination deficient mutants of the yeast Saccharomyces cerevisae. Three related but inactive compounds, oxoglaucine [3], O-methylmoschatoline [4], and lysicamine [5], were also isolated from this plant. Selective toxicity was also observed for 10-methoxyliriodenine (lauterine) [6] and 10-hydroxyliriodenine [7], two oxoaporphine Alkaloids isolated from Miliusa cf. banacea (Annonaceae). The structure of 10-hydroxyliriodenine [7], a novel oxoaporphine, was determined by spectroscopic methods and chemical conversion to compound 6. The role of the bioactive oxoaporphine Alkaloids as DNA Topoisomerase inhibitors is discussed.
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Cat. No.Product NameDescriptionTargetResearch Area
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target: TopoisomeraseResearch Areas: Infection
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