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Results for "

PIT1

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Isotope-Labeled Compounds

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0561
    Spironolactone
    5+ Cited Publications

    SC9420

    		 Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel Cardiovascular Disease Metabolic Disease Endocrinology Cancer
    Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects [1] .
    Spironolactone
  • HY-103224
    PIT-1

    		PI3K Cancer
    PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo [1].
    PIT-1
  • HY-124348
    DM-PIT-1

    3,5-Dimethyl PIT-1

    		 PI3K Cancer
    DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer [1] .
    DM-PIT-1
  • HY-103224R
    PIT-1 (Standard)

    		Reference Standards PI3K Cancer
    PIT-1 (Standard) is the analytical standard of PIT-1. This product is intended for research and analytical applications. PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo [1].
    PIT-1 (Standard)
  • HY-B0561S4
    Spironolactone-d6-1

    		Isotope-Labeled Compounds Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel Cardiovascular Disease Metabolic Disease Cancer
    Spironolactone-d6-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects [1] .
    Spironolactone-d6-1
  • HY-159978
    EOS789

    		Sodium Phosphate Cotransporter Metabolic Disease Inflammation/Immunology
    EOS789 is an orally active sodium-dependent phosphate transporter inhibitor, with IC50 values of 6.8, 1.5, and 1.7 μM against human NaPi-IIb, PiT-1, PiT-2, respectively; and IC50 values of 3.9, 1.9, and 1.7 μM against rat NaPi-IIb, PiT-1, PiT-2, respectively. EOS789 inhibits intestinal phosphate absorption, increases fecal phosphate excretion, reduces urinary phosphate excretion, and decreases the levels of serum phosphate, FGF23, and adult parathyroid hormone. EOS789 ameliorates ectopic thoracic aortic calcification, renal injury and hyperphosphatemia, and inhibits the expression of fibrosis markers. EOS789 can be used for the research of hyperphosphatemia and chronic kidney disease-mineral and bone disorder (CKD-MBD) [1] .
    EOS789
  • HY-RS13059
    SLC20A1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SLC20A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC20A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SLC20A1 Human Pre-designed siRNA Set A
    SLC20A1 Human Pre-designed siRNA Set A
  • HY-RS10895
    POU1F1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    POU1F1 Human Pre-designed siRNA Set A contains three designed siRNAs for POU1F1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    POU1F1 Human Pre-designed siRNA Set A
    POU1F1 Human Pre-designed siRNA Set A
  • HY-RS28552
    Slc20a1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    Slc20a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc20a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Slc20a1 Rat Pre-designed siRNA Set A
    Slc20a1 Rat Pre-designed siRNA Set A
  • HY-182689
    LY3358966

    		Sodium Phosphate Cotransporter Metabolic Disease Endocrinology
    LY3358966 is an orally active sodium-dependent phosphate cotransporter 2b (NPT2b) inhibitor with a human IC50 of 32.4 nM, mouse IC50 of 43.9 nM, and rat of IC50 26.8 nM. LY3358966 inhibits NPT2b-mediated intestinal phosphate transport, decreases acute phosphate uptake into plasma, and increases fecal phosphate excretion. LY3358966 can be used for the research of renal disease [1].
    LY3358966

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