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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
PPP1R15A
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "PPP1R15A" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: Sephin1; IFB-088
Target:
Research Areas:
Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .
Cat. No.: HY-RS10986
Target:
Research Areas:
PPP1R15A Human Pre-designed siRNA Set A contains three designed siRNAs for PPP1R15A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-18956
CAS No.: 13098-73-2
Synonyms: (E/Z)-Sephin1; (E/Z)-IFB-088
Target:
Research Areas:
(E/Z)-Icerguastat ((E/Z)-Sephin1) is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). (E/Z)-Icerguastat can be used for protein misfolding diseases research .
Cat. No.: HY-RS17569
Target:
Research Areas:
Ppp1r15a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppp1r15a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24029
Target:
Research Areas:
Ppp1r15a Rat Pre-designed siRNA Set A contains three designed siRNAs for Ppp1r15a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-18956B
CAS No.: 469866-31-7
Synonyms: (E/Z)-Sephin1 acetate; (E/Z)-IFB-088 acetate
Target:
Research Areas:
(E/Z)-Icerguastat ((E/Z)-Sephin1) acetate is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). (E/Z)-Icerguastat acetate can be used for protein misfolding diseases research .
Cat. No.: HY-110365
CAS No.: 1883549-35-6
Synonyms: Sephin1 Carbonate; IFB-088 Carbonate
Target:
Research Areas:
Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .
Cat. No.: HY-P705526
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PPP1R15A; Myeloid Differentiation Primary Response Protein MyD116 Homolog; Protein Phosphatase 1 Regulatory Subunit 15A; Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A; GADD34; Growth Arrest And DNA-Damage-Inducible 34; Growth Arrest And DNA Da
Cat. No.: HY-18956A
CAS No.: 32597-86-7
Synonyms: (E/Z)-Sephin1 hydrochloride; (E/Z)-IFB-088 hydrochloride
Target:
Research Areas:
(E/Z)-Icerguastat hydrochloride ((E/Z)-Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2α. (E/Z)-Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z)-Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z)-Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains .
Cat. No.: HY-111022R
CAS No.: 951441-04-6
Synonyms: Sephin1 (Standard); IFB-088 (Standard)
Target:
Research Areas:
Icerguastat (Standard) is the analytical standard of Icerguastat (HY-111022). This product is intended for research and analytical applications. Icerguastat (Sephin1), a derivative of Guanabenz lacKing the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
