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Cat. No.: HY-111022R

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Icerguastat (Standard)

Name: Icerguastat (Standard)
Brand: MedChemExpress
SKU: HY-111022R
Availability: PreOrder

(Synonyms: Sephin1 (Standard); IFB-088 (Standard))

Icerguastat (Standard) is the analytical standard of Icerguastat (HY-111022). This product is intended for research and analytical applications. Icerguastat (Sephin1), a derivative of Guanabenz lacK_ing the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect.

For research use only. We do not sell to patients.

CAS No.: 951441-04-6
Formula: C₈H₉ClN₄
Molecular Weight:196.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Icerguastat (Standard) Chemical Structure

CAS No.: 951441-04-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 951441-04-6
Molecular Weight 196.64
Formula C₈H₉ClN₄
SMILES

ClC1=CC=CC=C1/C=N/NC(N)=N
Synonyms

Sephin1 (Standard); IFB-088 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen Y, et al. Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. Brain. 2019;142(2):344-361. [Content Brief]

[2]. Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015;348(6231):239-242. [Content Brief]

[3]. Thapa S, et al. Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model. Mol Neurobiol. 2020;57(5):2206-2219. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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