951441-04-6
951441-04-6
Chemical Structure
Icerguastat
Synonym(s): Sephin1; IFB-088
- CAS No.: 951441-04-6
- Formula:C8H9ClN4
- Molecular Weight:196.64
IUPAC Name: (E)-2-(2-chlorobenzylidene)hydrazine-1-carboximidamide
InChIKey: PDWJALXSRRSUHR-LFYBBSHMSA-N
SMILES: ClC1=CC=CC=C1/C=N/NC(N)=N
Biological Activity: Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect[1][2][3].
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Icerguastat | 99.93% | Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect. | ||||||||||||||||||||
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References
- [1]. Chen Y, et al. Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. Brain. 2019;142(2):344-361. [Content Brief]
- [2]. Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015;348(6231):239-242. [Content Brief]
- [3]. Thapa S, et al. Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model. Mol Neurobiol. 2020;57(5):2206-2219. [Content Brief]
Keywords
