9 Results for "

PSD-95/nNOS

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "PSD-95/nNOS" in MCE Product Catalog:

8
8 Publications Verification
Cat. No.: HY-P0117
CAS No.: 500992-11-0
Synonyms: Tat-NR2Bct; NA-1
Target:  

iGluR NO Synthase

Research Areas:  

Neurological Disease

Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
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8
8 Publications Verification
Cat. No.: HY-P0117A
CAS No.: 1834571-04-8
Synonyms: Tat-NR2Bct TFA; NA-1 TFA
Target:  

iGluR NO Synthase

Research Areas:  

Neurological Disease

Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
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2
2 Cited Publications
Cat. No.: HY-100456
CAS No.: 1181226-02-7
Purity:  99.23%
Target:  

iGluR

Research Areas:  

Neurological Disease

ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis.
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2
2 Cited Publications
Cat. No.: HY-100457
CAS No.: 866927-10-8
Purity:  97.24%
Target:  

iGluR

Research Areas:  

Neurological Disease

IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.
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Cat. No.: HY-175824
PSD-95/nNOS PPI-IN-1 is a inhibitor targeting the PSD-95/nNOS interaction with potential blood-brain barrier penetration. PSD-95/nNOS PPI-IN-1 binds to the PSD-95 PDZ2 domain with high affinity (Ki = 19.45 μM). PSD-95/nNOS PPI-IN-1 inhibits glutamate-induced excitotoxicity by reducing intracellular ROS levels and inhibiting apoptosis. PSD-95/nNOS PPI-IN-1 significantly reduces cerebral infarct volume in rat tMCAO models. PSD-95/nNOS PPI-IN-1 can be used for the study of acute ischemic stroke .
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Cat. No.: HY-155355
Target:  

iGluR

Research Areas:  

Neurological Disease

LY836 is an orally active neuroprotective agent. LY836 significantly blocks PSD95-nNOS association in cortical neurons. LY836 can be used in study ischemic stroke .
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Cat. No.: HY-100457R
CAS No.: 866927-10-8
Research Areas:  

Neurological Disease

IC87201 (Standard) is the analytical standard of IC87201 (HY-100457). This product is intended for research and analytical applications. IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.
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Cat. No.: HY-100456R
CAS No.: 1181226-02-7
Research Areas:  

Neurological Disease

ZL006 (Standard) is the analytical standard of ZL006 (HY-100456). This product is intended for research and analytical applications. ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis.
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Cat. No.: HY-184108
CAS No.: 2486316-20-3
Research Areas:  

Neurological Disease

ZL006-05 is an orally active, brain-penetrant nNOS–PSD-95 and α2-containing GABAA dual-target inhibitor. ZL006-05 blocks the nNOS-PSD-95 protein-protein interaction and selectively potentiatesα2-containing GABAA receptors. ZL006-05 attenuates central sensitization and strengthens inhibitory GABAergic synaptic transmission. ZL006-05 can be used for the study of neuropathic pain, cancer pain, chemotherapy-induced peripheral neuropathic pain, ischemic stroke, poststroke depression and anxiety .
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